Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers
Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymo...
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| Veröffentlicht in: | Frontiers in immunology 2021-07, Vol.12, p.681810, Article 681810 |
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| creator | Meng, Leilei Song, Zichen Liu, Anding Dahmen, Uta Yang, Xiao Fang, Haoshu |
| description | Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymorphisms (SNPs), may account for predisposition and clinical outcome of diseases. Lipopolysaccharide (LPS)-binding protein (LBP) functions as an enhancer of the host response to LPS, the main component of the outer membrane of gram-native bacteria. Given the crucial role of LBP in inflammation, we will review the impact of SNPs in the LBP gene on infections and inflammatory diseases, metabolic disorders and cancers. |
| doi_str_mv | 10.3389/fimmu.2021.681810 |
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Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymorphisms (SNPs), may account for predisposition and clinical outcome of diseases. Lipopolysaccharide (LPS)-binding protein (LBP) functions as an enhancer of the host response to LPS, the main component of the outer membrane of gram-native bacteria. 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Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymorphisms (SNPs), may account for predisposition and clinical outcome of diseases. Lipopolysaccharide (LPS)-binding protein (LBP) functions as an enhancer of the host response to LPS, the main component of the outer membrane of gram-native bacteria. 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Song, Zichen ; Liu, Anding ; Dahmen, Uta ; Yang, Xiao ; Fang, Haoshu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-9f73327f82cd2f96ba26d88649336045ef18a5928b05422fb9e8554675119a7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute-Phase Proteins - genetics</topic><topic>Acute-Phase Proteins - metabolism</topic><topic>Alleles</topic><topic>Animals</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>Communicable Diseases - etiology</topic><topic>Communicable Diseases - metabolism</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Immunology</topic><topic>infections</topic><topic>inflammation</topic><topic>Inflammation - genetics</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>inflammatory diseases</topic><topic>Life Sciences & Biomedicine</topic><topic>lipopolysaccharide-binding protein</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Metabolic Diseases - diagnosis</topic><topic>Metabolic Diseases - genetics</topic><topic>Metabolic Diseases - metabolism</topic><topic>metabolic disorders</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Science & Technology</topic><topic>single nucleotide polymorphisms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meng, Leilei</creatorcontrib><creatorcontrib>Song, Zichen</creatorcontrib><creatorcontrib>Liu, Anding</creatorcontrib><creatorcontrib>Dahmen, Uta</creatorcontrib><creatorcontrib>Yang, Xiao</creatorcontrib><creatorcontrib>Fang, Haoshu</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meng, Leilei</au><au>Song, Zichen</au><au>Liu, Anding</au><au>Dahmen, Uta</au><au>Yang, Xiao</au><au>Fang, Haoshu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers</atitle><jtitle>Frontiers in immunology</jtitle><stitle>FRONT IMMUNOL</stitle><addtitle>Front Immunol</addtitle><date>2021-07-06</date><risdate>2021</risdate><volume>12</volume><spage>681810</spage><pages>681810-</pages><artnum>681810</artnum><issn>1664-3224</issn><eissn>1664-3224</eissn><abstract>Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. 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| subjects | Acute-Phase Proteins - genetics Acute-Phase Proteins - metabolism Alleles Animals Carrier Proteins - genetics Carrier Proteins - metabolism Communicable Diseases - etiology Communicable Diseases - metabolism Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Immunology infections inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology inflammatory diseases Life Sciences & Biomedicine lipopolysaccharide-binding protein Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Metabolic Diseases - diagnosis Metabolic Diseases - genetics Metabolic Diseases - metabolism metabolic disorders Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Polymorphism, Single Nucleotide Science & Technology single nucleotide polymorphisms |
| title | Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers |
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