Palladium-Catalyzed Direct C2-Biarylation of Indoles

Palladium-Catalyzed Direct C2-Biarylation of Indoles

Biaryl and indole units are important structural motifs in several bioactive molecules and functional materials. We have accomplished straightforward access to C2-biarylated indole derivatives through palladium-catalyzed C–H activation strategy with a broad range of substrate scope in yields of 24 t...

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Veröffentlicht in:Journal of organic chemistry 2021-08, Vol.86 (15), p.10838-10851
Hauptverfasser: Murugesan, Tamilarasu, Sivarajan, Chinraj, Jayakumari, Chithra Mohan, Singh, Rajat Kumar, Vennapusa, Sivaranjana Reddy, Kaliyamoorthy, Alagiri
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container_end_page 10851
container_issue 15
container_start_page 10838
container_title Journal of organic chemistry
container_volume 86
creator Murugesan, Tamilarasu
Sivarajan, Chinraj
Jayakumari, Chithra Mohan
Singh, Rajat Kumar
Vennapusa, Sivaranjana Reddy
Kaliyamoorthy, Alagiri
description Biaryl and indole units are important structural motifs in several bioactive molecules and functional materials. We have accomplished straightforward access to C2-biarylated indole derivatives through palladium-catalyzed C–H activation strategy with a broad range of substrate scope in yields of 24 to 92%. Besides, the UV/visible absorption and fluorescence properties of the ensuing products were explored. The calculated higher dihedral angle and rotational barrier values for the selected C2-biarylated indoles show that these compounds may display atropisomerism at room temperature.
doi_str_mv 10.1021/acs.joc.1c01123
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title Palladium-Catalyzed Direct C2-Biarylation of Indoles
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