SAR1B senses leucine levels to regulate mTORC1 signalling

The mTOR complex 1 (mTORC1) controls cell growth in response to amino acid levels 1 . Here we report SAR1B as a leucine sensor that regulates mTORC1 signalling in response to intracellular levels of leucine. Under conditions of leucine deficiency, SAR1B inhibits mTORC1 by physically targeting its ac...

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Veröffentlicht in:	Nature (London) 2021-08, Vol.596 (7871), p.281-284
Hauptverfasser:	Chen, Jie, Ou, Yuhui, Luo, Rong, Wang, Jie, Wang, Dong, Guan, Jialiang, Li, Yi, Xia, Peixue, Chen, Peng R., Liu, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/89 13/95 631/80 631/80/86/2369 64/11 82 82/29 82/58 82/83 96 96/63 Amino acids Animals Binding sites Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Causes of Cell growth Chemical properties Conserved Sequence GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism HEK293 Cells Humanities and Social Sciences Humans Intracellular levels Intracellular signalling Leucine Leucine - deficiency Leucine - metabolism Life span Localization Longevity - genetics Lung cancer Lung diseases Lung Neoplasms - genetics Lung Neoplasms - metabolism Mechanistic Target of Rapamycin Complex 1 - agonists Mechanistic Target of Rapamycin Complex 1 - metabolism Medical research Medicine, Experimental Mice Monomeric GTP-Binding Proteins - chemistry Monomeric GTP-Binding Proteins - deficiency Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism multidisciplinary Multiprotein Complexes - metabolism Nematodes Nuclear Proteins - metabolism Protein Binding Proteins Science Science (multidisciplinary) Sensors Signal Transduction Signaling TOR protein Tumor Suppressor Proteins - metabolism Tumors Xenograft Model Antitumor Assays
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