Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase–Carbonic Anhydrase Dual-Hybrid Inhibitors

Human (h) telomerase (TL; EC 2.7.7.49) plays a key role in sustaining cancer cells by means of elongating telomeric repeats at the 3′ ends of chromosomes. Since TL-inhibitor (TI) stand-alone cancer therapy has been proven to be remarkably challenging, a polypharmacological approach represents a vali...

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Veröffentlicht in:	Journal of medicinal chemistry 2021-08, Vol.64 (15), p.11432-11444
Hauptverfasser:	Plyasova, Anna A, Berrino, Emanuela, Khan, Irina I, Veselovsky, Alexander V, Pokrovsky, Vadim S, Angeli, Andrea, Ferraroni, Marta, Supuran, Claudiu T, Pokrovskaya, Marina V, Alexandrova, Svetlana S, Gladilina, Yulia A, Sokolov, Nikolay N, Hilal, Abdullah, Carta, Fabrizio, Zhdanov, Dmitry D
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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