Efficient RNA Virus Targeting via CRISPR/CasRx in Fish

The emergence of the CRISPR/Cas system as a technology has transformed our ability to modify nucleic acids, and the CRISPR/Cas13 system has been used to target RNA. CasRx is a small type VI-D effector (Cas13d) with RNA knockdown efficiency that may have an interference effect on RNA viruses. However...

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Veröffentlicht in:	Journal of virology 2021-09, Vol.95 (19), p.e0046121-e0046121
Hauptverfasser:	Wang, Qing, Liu, Yun, Han, Chong, Yang, Min, Huang, Fengqi, Duan, Xuzhuo, Wang, Shaowen, Yu, Yepin, Liu, Jiaxin, Yang, Huirong, Lu, Danqi, Zhao, Huihong, Zhang, Yong, Qin, Qiwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotechnology CRISPR-Associated Proteins - metabolism CRISPR-Cas Systems Fish Diseases - virology Nodaviridae - genetics Nodaviridae - physiology Perciformes - virology RNA Interference RNA Virus Infections - veterinary RNA Virus Infections - virology RNA, Viral - genetics Spotlight Spotlight Selection Vaccines and Antiviral Agents
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