Engineering Dirhodium Artificial Metalloenzymes for Diazo Coupling Cascade Reactions

Artificial metalloenzymes (ArMs) are commonly used to control the stereoselectivity of catalytic reactions, but controlling chemoselectivity remains challenging. In this study, we engineer a dirhodium ArM to catalyze diazo cross‐coupling to form an alkene that, in a one‐pot cascade reaction, is redu...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-10, Vol.60 (44), p.23672-23677
Hauptverfasser:	Upp, David M., Huang, Rui, Li, Ying, Bultman, Max J., Roux, Benoit, Lewis, Jared C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanes artificial metalloenzymes cascade catalysis Cascade chemical reactions Catalysis Catalysts Complex media Cross coupling Directed evolution dirhodium catalysis Enantiomers molecular dynamics simulations Reductases Rhodium compounds Side reactions Stereoselectivity Substrates
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