Quality control of Semen Hoveniae by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry
A method based on high‐performance liquid chromatography and Fourier transform‐ion cyclotron resonance mass spectrometry was developed to control the quality of Semen Hoveniae. First, the chromatographic fingerprint was established in combination with the chemometrics methods such as similarity anal...
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| Veröffentlicht in: | Journal of separation science 2021-09, Vol.44 (18), p.3366-3375 |
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| creator | Zhang, Qingyu Xu, Ke Zhang, Yu Han, Jing Sui, Wenwen Zhang, Haotian Yu, Maomao Tong, Yichen Wang, Sijie Han, Fei |
| description | A method based on high‐performance liquid chromatography and Fourier transform‐ion cyclotron resonance mass spectrometry was developed to control the quality of Semen Hoveniae. First, the chromatographic fingerprint was established in combination with the chemometrics methods such as similarity analysis, cluster analysis, principal component analysis, and orthogonal partial least squares discriminant analysis to discover the qualitative markers. Then, an high‐performance liquid chromatography mass spectrometry method was developed to identify the chemical constituents in Semen Hoveniae. Moreover, the content of dihydromyricetin and dihydroquercetin in Semen Hoveniae were determined by high‐performance liquid chromatography. As a result, nine common peaks were assigned in the fingerprints and the similarity of the 13 batch samples varied from 0.425 to 0.993, indicating an obviously different quality. Dihydromyricetin and dihydroquercetin were the main qualitative markers to differ the quality of Semen Hoveniae. Meanwhile, a total of 21 chemical compounds were characterized by high‐performance liquid chromatography mass spectrometry and six of them were identified by comparing with information of reference standards. Finally, the content of dihydromyricetin and dihydroquercetin in 13 batch samples varied from 0.824 to 7.499 mg/g and from 0.05941 to 4.258 mg/g , respectively. In conclusion, the methods developed here will provide sufficient qualitative and quantitative information for the quality control of Semen Hoveniae. |
| doi_str_mv | 10.1002/jssc.202100240 |
| format | Article |
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First, the chromatographic fingerprint was established in combination with the chemometrics methods such as similarity analysis, cluster analysis, principal component analysis, and orthogonal partial least squares discriminant analysis to discover the qualitative markers. Then, an high‐performance liquid chromatography mass spectrometry method was developed to identify the chemical constituents in Semen Hoveniae. Moreover, the content of dihydromyricetin and dihydroquercetin in Semen Hoveniae were determined by high‐performance liquid chromatography. As a result, nine common peaks were assigned in the fingerprints and the similarity of the 13 batch samples varied from 0.425 to 0.993, indicating an obviously different quality. Dihydromyricetin and dihydroquercetin were the main qualitative markers to differ the quality of Semen Hoveniae. Meanwhile, a total of 21 chemical compounds were characterized by high‐performance liquid chromatography mass spectrometry and six of them were identified by comparing with information of reference standards. Finally, the content of dihydromyricetin and dihydroquercetin in 13 batch samples varied from 0.824 to 7.499 mg/g and from 0.05941 to 4.258 mg/g , respectively. In conclusion, the methods developed here will provide sufficient qualitative and quantitative information for the quality control of Semen Hoveniae.</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.202100240</identifier><identifier>PMID: 34288432</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Chemical compounds ; Chromatographic fingerprint ; Chromatography ; Chromatography, High Pressure Liquid - methods ; Cluster analysis ; Cyclotron resonance ; Discriminant analysis ; Drugs, Chinese Herbal - analysis ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - standards ; Fingerprints ; Fourier transforms ; Fourier transform‐ion cyclotron resonance mass spectrometry ; Ions ; Linear Models ; Liquid chromatography ; Markers ; Mass spectrometry ; Mass Spectrometry - methods ; Principal components analysis ; Qualitative analysis ; Quality Control ; Reproducibility of Results ; Rhamnaceae - chemistry ; Scientific imaging ; Seeds - chemistry ; Semen ; Semen Hoveniae ; Similarity ; Spectroscopy ; Spectroscopy, Fourier Transform Infrared</subject><ispartof>Journal of separation science, 2021-09, Vol.44 (18), p.3366-3375</ispartof><rights>2021 Wiley‐VCH GmbH</rights><rights>2021 Wiley-VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3681-dfae95fec9e908efe9ee8c72689404ced0fbdc0effa62ec5a0cb7d2397c34f203</citedby><cites>FETCH-LOGICAL-c3681-dfae95fec9e908efe9ee8c72689404ced0fbdc0effa62ec5a0cb7d2397c34f203</cites><orcidid>0000-0002-6178-5118</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjssc.202100240$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjssc.202100240$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34288432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Qingyu</creatorcontrib><creatorcontrib>Xu, Ke</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Han, Jing</creatorcontrib><creatorcontrib>Sui, Wenwen</creatorcontrib><creatorcontrib>Zhang, Haotian</creatorcontrib><creatorcontrib>Yu, Maomao</creatorcontrib><creatorcontrib>Tong, Yichen</creatorcontrib><creatorcontrib>Wang, Sijie</creatorcontrib><creatorcontrib>Han, Fei</creatorcontrib><title>Quality control of Semen Hoveniae by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry</title><title>Journal of separation science</title><addtitle>J Sep Sci</addtitle><description>A method based on high‐performance liquid chromatography and Fourier transform‐ion cyclotron resonance mass spectrometry was developed to control the quality of Semen Hoveniae. First, the chromatographic fingerprint was established in combination with the chemometrics methods such as similarity analysis, cluster analysis, principal component analysis, and orthogonal partial least squares discriminant analysis to discover the qualitative markers. Then, an high‐performance liquid chromatography mass spectrometry method was developed to identify the chemical constituents in Semen Hoveniae. Moreover, the content of dihydromyricetin and dihydroquercetin in Semen Hoveniae were determined by high‐performance liquid chromatography. As a result, nine common peaks were assigned in the fingerprints and the similarity of the 13 batch samples varied from 0.425 to 0.993, indicating an obviously different quality. Dihydromyricetin and dihydroquercetin were the main qualitative markers to differ the quality of Semen Hoveniae. Meanwhile, a total of 21 chemical compounds were characterized by high‐performance liquid chromatography mass spectrometry and six of them were identified by comparing with information of reference standards. Finally, the content of dihydromyricetin and dihydroquercetin in 13 batch samples varied from 0.824 to 7.499 mg/g and from 0.05941 to 4.258 mg/g , respectively. In conclusion, the methods developed here will provide sufficient qualitative and quantitative information for the quality control of Semen Hoveniae.</description><subject>Chemical compounds</subject><subject>Chromatographic fingerprint</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Cluster analysis</subject><subject>Cyclotron resonance</subject><subject>Discriminant analysis</subject><subject>Drugs, Chinese Herbal - analysis</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - standards</subject><subject>Fingerprints</subject><subject>Fourier transforms</subject><subject>Fourier transform‐ion cyclotron resonance mass spectrometry</subject><subject>Ions</subject><subject>Linear Models</subject><subject>Liquid chromatography</subject><subject>Markers</subject><subject>Mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>Principal components analysis</subject><subject>Qualitative analysis</subject><subject>Quality Control</subject><subject>Reproducibility of Results</subject><subject>Rhamnaceae - chemistry</subject><subject>Scientific imaging</subject><subject>Seeds - chemistry</subject><subject>Semen</subject><subject>Semen Hoveniae</subject><subject>Similarity</subject><subject>Spectroscopy</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkbtuFDEUhi0UREKgTRlZSkOziy9zsUu0IiRRJIQW6pHXc5z1ymNP7BnQdHmEVDwgTxJPNmxBQ-Vj6zvf8dGP0BklS0oI-7hLSS8ZYfOlIK_QCa1ouZCcFkeHmlTH6G1KO0JoLSR5g455wYQoODtBv7-Nytlhwjr4IQaHg8Fr6MDjq_ATvFWANxPe2rvtn4fHHqIJsVNeA3b2frQt1tsYOjWEu6j67WwZewctHgK-DGO0EPEQlU9zWxbY4LGetAt5lMcRUvDPsk6lhFMPOr93MMTpHXptlEvw_uU8RT8uP39fXS1uv365Xn26XWheCbpojQJZGtASJBFgQAIIXbNKyIIUGlpiNq0mYIyqGOhSEb2pW8ZlrXlhGOGn6MPe28dwP0Iams4mDc4pD2FMDStLLmglOMvoxT_oLm_o8-8yVdeMybLmmVruKR1DShFM00fbqTg1lDRzSM2cWHNILDecv2jHTQftAf8bUQaKPfDLOpj-o2tu1utVzSvKnwDdh6j1</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Zhang, Qingyu</creator><creator>Xu, Ke</creator><creator>Zhang, Yu</creator><creator>Han, Jing</creator><creator>Sui, Wenwen</creator><creator>Zhang, Haotian</creator><creator>Yu, Maomao</creator><creator>Tong, Yichen</creator><creator>Wang, Sijie</creator><creator>Han, Fei</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6178-5118</orcidid></search><sort><creationdate>202109</creationdate><title>Quality control of Semen Hoveniae by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry</title><author>Zhang, Qingyu ; Xu, Ke ; Zhang, Yu ; Han, Jing ; Sui, Wenwen ; Zhang, Haotian ; Yu, Maomao ; Tong, Yichen ; Wang, Sijie ; Han, Fei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3681-dfae95fec9e908efe9ee8c72689404ced0fbdc0effa62ec5a0cb7d2397c34f203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chemical compounds</topic><topic>Chromatographic fingerprint</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Cluster analysis</topic><topic>Cyclotron resonance</topic><topic>Discriminant analysis</topic><topic>Drugs, Chinese Herbal - analysis</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - standards</topic><topic>Fingerprints</topic><topic>Fourier transforms</topic><topic>Fourier transform‐ion cyclotron resonance mass spectrometry</topic><topic>Ions</topic><topic>Linear Models</topic><topic>Liquid chromatography</topic><topic>Markers</topic><topic>Mass spectrometry</topic><topic>Mass Spectrometry - methods</topic><topic>Principal components analysis</topic><topic>Qualitative analysis</topic><topic>Quality Control</topic><topic>Reproducibility of Results</topic><topic>Rhamnaceae - chemistry</topic><topic>Scientific imaging</topic><topic>Seeds - chemistry</topic><topic>Semen</topic><topic>Semen Hoveniae</topic><topic>Similarity</topic><topic>Spectroscopy</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Qingyu</creatorcontrib><creatorcontrib>Xu, Ke</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Han, Jing</creatorcontrib><creatorcontrib>Sui, Wenwen</creatorcontrib><creatorcontrib>Zhang, Haotian</creatorcontrib><creatorcontrib>Yu, Maomao</creatorcontrib><creatorcontrib>Tong, Yichen</creatorcontrib><creatorcontrib>Wang, Sijie</creatorcontrib><creatorcontrib>Han, Fei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Qingyu</au><au>Xu, Ke</au><au>Zhang, Yu</au><au>Han, Jing</au><au>Sui, Wenwen</au><au>Zhang, Haotian</au><au>Yu, Maomao</au><au>Tong, Yichen</au><au>Wang, Sijie</au><au>Han, Fei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality control of Semen Hoveniae by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry</atitle><jtitle>Journal of separation science</jtitle><addtitle>J Sep Sci</addtitle><date>2021-09</date><risdate>2021</risdate><volume>44</volume><issue>18</issue><spage>3366</spage><epage>3375</epage><pages>3366-3375</pages><issn>1615-9306</issn><eissn>1615-9314</eissn><abstract>A method based on high‐performance liquid chromatography and Fourier transform‐ion cyclotron resonance mass spectrometry was developed to control the quality of Semen Hoveniae. First, the chromatographic fingerprint was established in combination with the chemometrics methods such as similarity analysis, cluster analysis, principal component analysis, and orthogonal partial least squares discriminant analysis to discover the qualitative markers. Then, an high‐performance liquid chromatography mass spectrometry method was developed to identify the chemical constituents in Semen Hoveniae. Moreover, the content of dihydromyricetin and dihydroquercetin in Semen Hoveniae were determined by high‐performance liquid chromatography. As a result, nine common peaks were assigned in the fingerprints and the similarity of the 13 batch samples varied from 0.425 to 0.993, indicating an obviously different quality. Dihydromyricetin and dihydroquercetin were the main qualitative markers to differ the quality of Semen Hoveniae. Meanwhile, a total of 21 chemical compounds were characterized by high‐performance liquid chromatography mass spectrometry and six of them were identified by comparing with information of reference standards. Finally, the content of dihydromyricetin and dihydroquercetin in 13 batch samples varied from 0.824 to 7.499 mg/g and from 0.05941 to 4.258 mg/g , respectively. In conclusion, the methods developed here will provide sufficient qualitative and quantitative information for the quality control of Semen Hoveniae.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34288432</pmid><doi>10.1002/jssc.202100240</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6178-5118</orcidid></addata></record> |
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| subjects | Chemical compounds Chromatographic fingerprint Chromatography Chromatography, High Pressure Liquid - methods Cluster analysis Cyclotron resonance Discriminant analysis Drugs, Chinese Herbal - analysis Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - standards Fingerprints Fourier transforms Fourier transform‐ion cyclotron resonance mass spectrometry Ions Linear Models Liquid chromatography Markers Mass spectrometry Mass Spectrometry - methods Principal components analysis Qualitative analysis Quality Control Reproducibility of Results Rhamnaceae - chemistry Scientific imaging Seeds - chemistry Semen Semen Hoveniae Similarity Spectroscopy Spectroscopy, Fourier Transform Infrared |
| title | Quality control of Semen Hoveniae by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry |
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