ASIC1a promotes the proliferation of synovial fibroblasts via the ERK/MAPK pathway

Synovial hyperplasia, a profound alteration in the structure of synovial tissue, is the basis for cumulative joint destruction in rheumatoid arthritis (RA). It is generally accepted that controlling synovial hyperplasia can delay the progression of RA. As one of the most intensively studied isoforms...

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Veröffentlicht in:	Laboratory investigation 2021-10, Vol.101 (10), p.1353-1362
Hauptverfasser:	Tao, Jingjing, Lu, Zheng, Su, Jingwen, Qian, Xuewen, Zhang, Yihao, Xu, Yayun, Song, Sujing, Hang, Xiaoyu, Peng, Xiaoqing, Chen, Feihu
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/51 13/89 14/1 14/19 14/35 631/337 631/80/304 82/51 82/80 Acid Sensing Ion Channels - metabolism Acidification Acidity Animals Antigens Arthritis Arthritis, Experimental - metabolism Calcium ions Calcium permeability Cell Proliferation - physiology Cells, Cultured Extracellular signal-regulated kinase Fibroblasts Fibroblasts - metabolism Humans Hyperplasia In vivo methods and tests Ion channels Isoforms Kinases Laboratory Medicine MAP kinase MAP Kinase Signaling System - physiology Medicine Medicine & Public Health Pathology Proliferating cell nuclear antigen Protein kinase Raf protein Rats Regulatory mechanisms (biology) Rheumatoid arthritis Signaling Sodium channels Synovial Membrane - chemistry Synovial Membrane - cytology Synovial Membrane - pathology Synovium
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