Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL

MyD88 gene mutation has been identified as one of the most prevalent driver mutations in the activated B-cell-like diffuse large B-cell lymphoma (ABC DLBCL). The published literature suggests that interleukin-1 receptor-associated kinase 1 (IRAK1) is an essential gene for ABC DLBCL harboring MyD88 m...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2021-08, Vol.64 (15), p.10878-10889
Hauptverfasser:	Fu, Liqiang, Zhang, Jing, Shen, Bin, Kong, Linglong, Liu, Yingtao, Tu, Wangyang, Wang, Wenqian, Cai, Xin, Wang, Xiaotao, Cheng, Na, Xia, Mingxuan, Zhou, Tianyuan, Liu, Qian, Xu, Yanping, Yang, Jennifer, Gavine, Paul, Philippar, Ulrike, Attar, Ricardo, Edwards, James P, Venable, Jennifer D, Dai, Xuedong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!