Design and rationale of a clinical trial to increase cardiomyocyte division in infants with tetralogy of Fallot

Patients with Tetralogy of Fallot with pulmonary stenosis (ToF/PS), the most common form of cyanotic congenital heart disease (CHD), develop adverse right ventricular (RV) remodeling, leading to late heart failure and arrhythmia. We recently demonstrated that overactive β-adrenergic receptor signali...

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Veröffentlicht in:	International journal of cardiology 2021-09, Vol.339, p.36-42
Hauptverfasser:	El Khoudary, Samar R., Fabio, Anthony, Yester, Jessie W., Steinhauser, Matthew L., Christopher, Adam B., Gyngard, Frank, Adams, Phillip S., Morell, Victor O., Viegas, Melita, Da Silva, Jose P., Da Silva, Luciana F., Castro-Medina, Mario, McCormick, Andrew, Reyes-Múgica, Miguel, Barlas, Michelle, Liu, Honghai, Thomas, Dawn, Ammanamanchi, Niyatie, Sada, Rachel, Cuda, Megan, Hartigan, Elizabeth, Groscost, David K., Kühn, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Beta-blocker Cardiomyocyte division Congenital heart disease Humans Infant Myocytes, Cardiac Pulmonary Valve Stenosis Randomized Controlled Trials as Topic Receptors, Adrenergic, beta-2 Tetralogy of Fallot Tetralogy of Fallot - diagnostic imaging Tetralogy of Fallot - surgery Ventricular hypertrophy Ventricular Remodeling
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