The survival after recurrence of colorectal cancer: a retrospective study focused on time to recurrence after curative resection
Purpose The significance of the duration of the recurrence-free survival after curative resection for colorectal cancer remains unclear. The purpose was to reveal the association between time to recurrence after surgery and the survival after recurrence. Methods Patients with stage II and III colore...
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| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2022-02, Vol.52 (2), p.239-250 |
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| creator | Furuke, Hirotaka Arita, Tomohiro Kuriu, Yoshiaki Shimizu, Hiroki Kiuchi, Jun Yamamoto, Yusuke Konishi, Hirotaka Morimura, Ryo Shiozaki, Atsushi Ikoma, Hisashi Kubota, Takeshi Nakanishi, Masayoshi Fujiwara, Hitoshi Okamoto, Kazuma Otsuji, Eigo |
| description | Purpose
The significance of the duration of the recurrence-free survival after curative resection for colorectal cancer remains unclear. The purpose was to reveal the association between time to recurrence after surgery and the survival after recurrence.
Methods
Patients with stage II and III colorectal cancer who underwent curative resection between 2007 and 2015 were retrospectively reviewed (
n
= 645). Patients with recurrence after surgery (
n
= 133) were divided into 2 groups: early recurrence (within 13 months after surgery,
n
= 63) and late recurrence (more than 13 months after surgery,
n
= 70). The overall survival after recurrence and clinicopathological features were compared between early recurrence, late recurrence, and without recurrence groups.
Results
The overall survival after recurrence was significantly shorter in patients with early recurrence occurring at less than 13 months (hazard ratio: 1.70,
p
= 0.03). A high preoperative CA19-9 level (odds ratio [OR]: 2.38,
p
= 0.03), venous invasion (OR: 2.26,
p
= 0.03), and the absence of adjuvant chemotherapy (OR: 2.08,
p
= 0.04) were independently correlated with early recurrence.
Conclusion
Early recurrence was associated with a poor prognosis after recurrence. Venous invasion correlated with early recurrence. Adjuvant chemotherapy may reduce the risk of early recurrence. These results indicate the importance of prudent surveillance and the aggressive application of adjuvant chemotherapy. |
| doi_str_mv | 10.1007/s00595-021-02336-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2552995420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2552995420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-4d2eb65421c299f0c1cd2aac5e455e137b4a5254be50a883b0e37f71366f7bbe3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EglL4ARbISzYBP_NghxAvCYlNWVuOM4FUaVzspBJd8elMm4JYsbDsmbn3WHMJOePskjOWXUXGdKETJjgeKdNkvUcmXOFD5FzukwkrFE-4KPgROY5xzphQOWOH5EgqkRa55hPyNXsHGoewala2pbbuIdAAbggBOgfU19T51mOnx7Gz2AvX1KKkDz4usd2s0N8P1SetvRsiVNR3tG8WQHv_lzSisbRbS4C4MfvuhBzUto1wurun5PX-bnb7mDy_PDzd3jwnTma8T1QloEy1EtyJoqiZ464S1joNSmvgMiuV1UKrEjSzeS5LBjKrMy7TtM7KEuSUXIzcZfAfA8TeLJrooG1tB36IRmiNYPyAoVSMUoc7xgC1WYZmYcOn4cxskjdj8gaTN9vkzRpN5zv-UC6g-rX8RI0COQoijro3CGbuh9Dhzv9hvwHQBJIc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2552995420</pqid></control><display><type>article</type><title>The survival after recurrence of colorectal cancer: a retrospective study focused on time to recurrence after curative resection</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Furuke, Hirotaka ; Arita, Tomohiro ; Kuriu, Yoshiaki ; Shimizu, Hiroki ; Kiuchi, Jun ; Yamamoto, Yusuke ; Konishi, Hirotaka ; Morimura, Ryo ; Shiozaki, Atsushi ; Ikoma, Hisashi ; Kubota, Takeshi ; Nakanishi, Masayoshi ; Fujiwara, Hitoshi ; Okamoto, Kazuma ; Otsuji, Eigo</creator><creatorcontrib>Furuke, Hirotaka ; Arita, Tomohiro ; Kuriu, Yoshiaki ; Shimizu, Hiroki ; Kiuchi, Jun ; Yamamoto, Yusuke ; Konishi, Hirotaka ; Morimura, Ryo ; Shiozaki, Atsushi ; Ikoma, Hisashi ; Kubota, Takeshi ; Nakanishi, Masayoshi ; Fujiwara, Hitoshi ; Okamoto, Kazuma ; Otsuji, Eigo</creatorcontrib><description>Purpose
The significance of the duration of the recurrence-free survival after curative resection for colorectal cancer remains unclear. The purpose was to reveal the association between time to recurrence after surgery and the survival after recurrence.
Methods
Patients with stage II and III colorectal cancer who underwent curative resection between 2007 and 2015 were retrospectively reviewed (
n
= 645). Patients with recurrence after surgery (
n
= 133) were divided into 2 groups: early recurrence (within 13 months after surgery,
n
= 63) and late recurrence (more than 13 months after surgery,
n
= 70). The overall survival after recurrence and clinicopathological features were compared between early recurrence, late recurrence, and without recurrence groups.
Results
The overall survival after recurrence was significantly shorter in patients with early recurrence occurring at less than 13 months (hazard ratio: 1.70,
p
= 0.03). A high preoperative CA19-9 level (odds ratio [OR]: 2.38,
p
= 0.03), venous invasion (OR: 2.26,
p
= 0.03), and the absence of adjuvant chemotherapy (OR: 2.08,
p
= 0.04) were independently correlated with early recurrence.
Conclusion
Early recurrence was associated with a poor prognosis after recurrence. Venous invasion correlated with early recurrence. Adjuvant chemotherapy may reduce the risk of early recurrence. These results indicate the importance of prudent surveillance and the aggressive application of adjuvant chemotherapy.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-021-02336-z</identifier><identifier>PMID: 34269851</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Chemotherapy, Adjuvant ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Digestive System Surgical Procedures - methods ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - prevention & control ; Neoplasm Staging ; Original Article ; Retrospective Studies ; Surgery ; Surgical Oncology ; Time Factors ; Young Adult</subject><ispartof>Surgery today (Tokyo, Japan), 2022-02, Vol.52 (2), p.239-250</ispartof><rights>Springer Nature Singapore Pte Ltd. 2021</rights><rights>2021. Springer Nature Singapore Pte Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-4d2eb65421c299f0c1cd2aac5e455e137b4a5254be50a883b0e37f71366f7bbe3</citedby><cites>FETCH-LOGICAL-c371t-4d2eb65421c299f0c1cd2aac5e455e137b4a5254be50a883b0e37f71366f7bbe3</cites><orcidid>0000-0001-7127-6504</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-021-02336-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-021-02336-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34269851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furuke, Hirotaka</creatorcontrib><creatorcontrib>Arita, Tomohiro</creatorcontrib><creatorcontrib>Kuriu, Yoshiaki</creatorcontrib><creatorcontrib>Shimizu, Hiroki</creatorcontrib><creatorcontrib>Kiuchi, Jun</creatorcontrib><creatorcontrib>Yamamoto, Yusuke</creatorcontrib><creatorcontrib>Konishi, Hirotaka</creatorcontrib><creatorcontrib>Morimura, Ryo</creatorcontrib><creatorcontrib>Shiozaki, Atsushi</creatorcontrib><creatorcontrib>Ikoma, Hisashi</creatorcontrib><creatorcontrib>Kubota, Takeshi</creatorcontrib><creatorcontrib>Nakanishi, Masayoshi</creatorcontrib><creatorcontrib>Fujiwara, Hitoshi</creatorcontrib><creatorcontrib>Okamoto, Kazuma</creatorcontrib><creatorcontrib>Otsuji, Eigo</creatorcontrib><title>The survival after recurrence of colorectal cancer: a retrospective study focused on time to recurrence after curative resection</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>Purpose
The significance of the duration of the recurrence-free survival after curative resection for colorectal cancer remains unclear. The purpose was to reveal the association between time to recurrence after surgery and the survival after recurrence.
Methods
Patients with stage II and III colorectal cancer who underwent curative resection between 2007 and 2015 were retrospectively reviewed (
n
= 645). Patients with recurrence after surgery (
n
= 133) were divided into 2 groups: early recurrence (within 13 months after surgery,
n
= 63) and late recurrence (more than 13 months after surgery,
n
= 70). The overall survival after recurrence and clinicopathological features were compared between early recurrence, late recurrence, and without recurrence groups.
Results
The overall survival after recurrence was significantly shorter in patients with early recurrence occurring at less than 13 months (hazard ratio: 1.70,
p
= 0.03). A high preoperative CA19-9 level (odds ratio [OR]: 2.38,
p
= 0.03), venous invasion (OR: 2.26,
p
= 0.03), and the absence of adjuvant chemotherapy (OR: 2.08,
p
= 0.04) were independently correlated with early recurrence.
Conclusion
Early recurrence was associated with a poor prognosis after recurrence. Venous invasion correlated with early recurrence. Adjuvant chemotherapy may reduce the risk of early recurrence. These results indicate the importance of prudent surveillance and the aggressive application of adjuvant chemotherapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Chemotherapy, Adjuvant</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Digestive System Surgical Procedures - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - prevention & control</subject><subject>Neoplasm Staging</subject><subject>Original Article</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EglL4ARbISzYBP_NghxAvCYlNWVuOM4FUaVzspBJd8elMm4JYsbDsmbn3WHMJOePskjOWXUXGdKETJjgeKdNkvUcmXOFD5FzukwkrFE-4KPgROY5xzphQOWOH5EgqkRa55hPyNXsHGoewala2pbbuIdAAbggBOgfU19T51mOnx7Gz2AvX1KKkDz4usd2s0N8P1SetvRsiVNR3tG8WQHv_lzSisbRbS4C4MfvuhBzUto1wurun5PX-bnb7mDy_PDzd3jwnTma8T1QloEy1EtyJoqiZ464S1joNSmvgMiuV1UKrEjSzeS5LBjKrMy7TtM7KEuSUXIzcZfAfA8TeLJrooG1tB36IRmiNYPyAoVSMUoc7xgC1WYZmYcOn4cxskjdj8gaTN9vkzRpN5zv-UC6g-rX8RI0COQoijro3CGbuh9Dhzv9hvwHQBJIc</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Furuke, Hirotaka</creator><creator>Arita, Tomohiro</creator><creator>Kuriu, Yoshiaki</creator><creator>Shimizu, Hiroki</creator><creator>Kiuchi, Jun</creator><creator>Yamamoto, Yusuke</creator><creator>Konishi, Hirotaka</creator><creator>Morimura, Ryo</creator><creator>Shiozaki, Atsushi</creator><creator>Ikoma, Hisashi</creator><creator>Kubota, Takeshi</creator><creator>Nakanishi, Masayoshi</creator><creator>Fujiwara, Hitoshi</creator><creator>Okamoto, Kazuma</creator><creator>Otsuji, Eigo</creator><general>Springer Singapore</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7127-6504</orcidid></search><sort><creationdate>20220201</creationdate><title>The survival after recurrence of colorectal cancer: a retrospective study focused on time to recurrence after curative resection</title><author>Furuke, Hirotaka ; Arita, Tomohiro ; Kuriu, Yoshiaki ; Shimizu, Hiroki ; Kiuchi, Jun ; Yamamoto, Yusuke ; Konishi, Hirotaka ; Morimura, Ryo ; Shiozaki, Atsushi ; Ikoma, Hisashi ; Kubota, Takeshi ; Nakanishi, Masayoshi ; Fujiwara, Hitoshi ; Okamoto, Kazuma ; Otsuji, Eigo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-4d2eb65421c299f0c1cd2aac5e455e137b4a5254be50a883b0e37f71366f7bbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Chemotherapy, Adjuvant</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Digestive System Surgical Procedures - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - prevention & control</topic><topic>Neoplasm Staging</topic><topic>Original Article</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furuke, Hirotaka</creatorcontrib><creatorcontrib>Arita, Tomohiro</creatorcontrib><creatorcontrib>Kuriu, Yoshiaki</creatorcontrib><creatorcontrib>Shimizu, Hiroki</creatorcontrib><creatorcontrib>Kiuchi, Jun</creatorcontrib><creatorcontrib>Yamamoto, Yusuke</creatorcontrib><creatorcontrib>Konishi, Hirotaka</creatorcontrib><creatorcontrib>Morimura, Ryo</creatorcontrib><creatorcontrib>Shiozaki, Atsushi</creatorcontrib><creatorcontrib>Ikoma, Hisashi</creatorcontrib><creatorcontrib>Kubota, Takeshi</creatorcontrib><creatorcontrib>Nakanishi, Masayoshi</creatorcontrib><creatorcontrib>Fujiwara, Hitoshi</creatorcontrib><creatorcontrib>Okamoto, Kazuma</creatorcontrib><creatorcontrib>Otsuji, Eigo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furuke, Hirotaka</au><au>Arita, Tomohiro</au><au>Kuriu, Yoshiaki</au><au>Shimizu, Hiroki</au><au>Kiuchi, Jun</au><au>Yamamoto, Yusuke</au><au>Konishi, Hirotaka</au><au>Morimura, Ryo</au><au>Shiozaki, Atsushi</au><au>Ikoma, Hisashi</au><au>Kubota, Takeshi</au><au>Nakanishi, Masayoshi</au><au>Fujiwara, Hitoshi</au><au>Okamoto, Kazuma</au><au>Otsuji, Eigo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The survival after recurrence of colorectal cancer: a retrospective study focused on time to recurrence after curative resection</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>52</volume><issue>2</issue><spage>239</spage><epage>250</epage><pages>239-250</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Purpose
The significance of the duration of the recurrence-free survival after curative resection for colorectal cancer remains unclear. The purpose was to reveal the association between time to recurrence after surgery and the survival after recurrence.
Methods
Patients with stage II and III colorectal cancer who underwent curative resection between 2007 and 2015 were retrospectively reviewed (
n
= 645). Patients with recurrence after surgery (
n
= 133) were divided into 2 groups: early recurrence (within 13 months after surgery,
n
= 63) and late recurrence (more than 13 months after surgery,
n
= 70). The overall survival after recurrence and clinicopathological features were compared between early recurrence, late recurrence, and without recurrence groups.
Results
The overall survival after recurrence was significantly shorter in patients with early recurrence occurring at less than 13 months (hazard ratio: 1.70,
p
= 0.03). A high preoperative CA19-9 level (odds ratio [OR]: 2.38,
p
= 0.03), venous invasion (OR: 2.26,
p
= 0.03), and the absence of adjuvant chemotherapy (OR: 2.08,
p
= 0.04) were independently correlated with early recurrence.
Conclusion
Early recurrence was associated with a poor prognosis after recurrence. Venous invasion correlated with early recurrence. Adjuvant chemotherapy may reduce the risk of early recurrence. These results indicate the importance of prudent surveillance and the aggressive application of adjuvant chemotherapy.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>34269851</pmid><doi>10.1007/s00595-021-02336-z</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7127-6504</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-1291 |
| ispartof | Surgery today (Tokyo, Japan), 2022-02, Vol.52 (2), p.239-250 |
| issn | 0941-1291 1436-2813 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Aged, 80 and over Chemotherapy, Adjuvant Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Digestive System Surgical Procedures - methods Female Humans Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - prevention & control Neoplasm Staging Original Article Retrospective Studies Surgery Surgical Oncology Time Factors Young Adult |
| title | The survival after recurrence of colorectal cancer: a retrospective study focused on time to recurrence after curative resection |
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