Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus

Endometriosis, polycystic ovary syndrome (PCOS) and uterine fibroids have been proposed as endometrial cancer risk factors; however, disentangling their relationships with endometrial cancer is complicated due to shared risk factors and comorbidities. Using genome-wide association study (GWAS) data,...

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Veröffentlicht in:	Human genetics 2021-09, Vol.140 (9), p.1353-1365
Hauptverfasser:	Kho, Pik Fang, Mortlock, Sally, Rogers, Peter A. W., Nyholt, Dale R., Montgomery, Grant W., Spurdle, Amanda B., Glubb, Dylan M., O’Mara, Tracy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Body mass index Cancer Chromosome 1 Comorbidity Endometrial cancer Endometriosis Endometrium Fibroids Gene Function Genetic analysis Genetic aspects Genetic relationship Genome-wide association studies Genomes Genomics Gynecological diseases Gynecology Health aspects Health risk assessment Human Genetics Metabolic Diseases Molecular Medicine Oncology, Experimental Original Investigation Polycystic ovary syndrome Reproductive system Risk factors Stein-Leventhal syndrome Uterine cancer Uterine fibroids Uterus Wnt protein
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