Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus
Endometriosis, polycystic ovary syndrome (PCOS) and uterine fibroids have been proposed as endometrial cancer risk factors; however, disentangling their relationships with endometrial cancer is complicated due to shared risk factors and comorbidities. Using genome-wide association study (GWAS) data,...
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| Veröffentlicht in: | Human genetics 2021-09, Vol.140 (9), p.1353-1365 |
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| creator | Kho, Pik Fang Mortlock, Sally Rogers, Peter A. W. Nyholt, Dale R. Montgomery, Grant W. Spurdle, Amanda B. Glubb, Dylan M. O’Mara, Tracy A. |
| description | Endometriosis, polycystic ovary syndrome (PCOS) and uterine fibroids have been proposed as endometrial cancer risk factors; however, disentangling their relationships with endometrial cancer is complicated due to shared risk factors and comorbidities. Using genome-wide association study (GWAS) data, we explored the relationships between these non-cancerous gynecological diseases and endometrial cancer risk by assessing genetic correlation, causal relationships and shared risk loci. We found significant genetic correlation between endometrial cancer and PCOS, and uterine fibroids. Adjustment for genetically predicted body mass index (a risk factor for PCOS, uterine fibroids and endometrial cancer) substantially attenuated the genetic correlation between endometrial cancer and PCOS but did not affect the correlation with uterine fibroids. Mendelian randomization analyses suggested a causal relationship between only uterine fibroids and endometrial cancer. Gene-based analyses revealed risk regions shared between endometrial cancer and endometriosis, and uterine fibroids. Multi-trait GWAS analysis of endometrial cancer and the genetically correlated gynecological diseases identified a novel genome-wide significant endometrial cancer risk locus at 1p36.12, which replicated in an independent endometrial cancer dataset. Interrogation of functional genomic data at 1p36.12 revealed biologically relevant genes, including
WNT4
which is necessary for the development of the female reproductive system. In summary, our study provides genetic evidence for a causal relationship between uterine fibroids and endometrial cancer. It further provides evidence that the comorbidity of endometrial cancer, PCOS and uterine fibroids may partly be due to shared genetic architecture. Notably, this shared architecture has revealed a novel genome-wide risk locus for endometrial cancer. |
| doi_str_mv | 10.1007/s00439-021-02312-0 |
| format | Article |
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WNT4
which is necessary for the development of the female reproductive system. In summary, our study provides genetic evidence for a causal relationship between uterine fibroids and endometrial cancer. It further provides evidence that the comorbidity of endometrial cancer, PCOS and uterine fibroids may partly be due to shared genetic architecture. Notably, this shared architecture has revealed a novel genome-wide risk locus for endometrial cancer.</description><identifier>ISSN: 0340-6717</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/s00439-021-02312-0</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Body mass index ; Cancer ; Chromosome 1 ; Comorbidity ; Endometrial cancer ; Endometriosis ; Endometrium ; Fibroids ; Gene Function ; Genetic analysis ; Genetic aspects ; Genetic relationship ; Genome-wide association studies ; Genomes ; Genomics ; Gynecological diseases ; Gynecology ; Health aspects ; Health risk assessment ; Human Genetics ; Metabolic Diseases ; Molecular Medicine ; Oncology, Experimental ; Original Investigation ; Polycystic ovary syndrome ; Reproductive system ; Risk factors ; Stein-Leventhal syndrome ; Uterine cancer ; Uterine fibroids ; Uterus ; Wnt protein</subject><ispartof>Human genetics, 2021-09, Vol.140 (9), p.1353-1365</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-e2876724c8a19857baa4db12a3066dda82c4617ee767835f87c27da512d0bff33</citedby><cites>FETCH-LOGICAL-c497t-e2876724c8a19857baa4db12a3066dda82c4617ee767835f87c27da512d0bff33</cites><orcidid>0000-0002-5436-3232</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00439-021-02312-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00439-021-02312-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27925,27926,41489,42558,51320</link.rule.ids></links><search><creatorcontrib>Kho, Pik Fang</creatorcontrib><creatorcontrib>Mortlock, Sally</creatorcontrib><creatorcontrib>Rogers, Peter A. W.</creatorcontrib><creatorcontrib>Nyholt, Dale R.</creatorcontrib><creatorcontrib>Montgomery, Grant W.</creatorcontrib><creatorcontrib>Spurdle, Amanda B.</creatorcontrib><creatorcontrib>Glubb, Dylan M.</creatorcontrib><creatorcontrib>O’Mara, Tracy A.</creatorcontrib><creatorcontrib>Endometrial Cancer Association Consortium</creatorcontrib><creatorcontrib>International Endometriosis Genetics Consortium</creatorcontrib><creatorcontrib>iPSYCH-SSI-Broad Groupw</creatorcontrib><title>Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><description>Endometriosis, polycystic ovary syndrome (PCOS) and uterine fibroids have been proposed as endometrial cancer risk factors; however, disentangling their relationships with endometrial cancer is complicated due to shared risk factors and comorbidities. Using genome-wide association study (GWAS) data, we explored the relationships between these non-cancerous gynecological diseases and endometrial cancer risk by assessing genetic correlation, causal relationships and shared risk loci. We found significant genetic correlation between endometrial cancer and PCOS, and uterine fibroids. Adjustment for genetically predicted body mass index (a risk factor for PCOS, uterine fibroids and endometrial cancer) substantially attenuated the genetic correlation between endometrial cancer and PCOS but did not affect the correlation with uterine fibroids. Mendelian randomization analyses suggested a causal relationship between only uterine fibroids and endometrial cancer. Gene-based analyses revealed risk regions shared between endometrial cancer and endometriosis, and uterine fibroids. Multi-trait GWAS analysis of endometrial cancer and the genetically correlated gynecological diseases identified a novel genome-wide significant endometrial cancer risk locus at 1p36.12, which replicated in an independent endometrial cancer dataset. Interrogation of functional genomic data at 1p36.12 revealed biologically relevant genes, including
WNT4
which is necessary for the development of the female reproductive system. In summary, our study provides genetic evidence for a causal relationship between uterine fibroids and endometrial cancer. It further provides evidence that the comorbidity of endometrial cancer, PCOS and uterine fibroids may partly be due to shared genetic architecture. Notably, this shared architecture has revealed a novel genome-wide risk locus for endometrial cancer.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body mass index</subject><subject>Cancer</subject><subject>Chromosome 1</subject><subject>Comorbidity</subject><subject>Endometrial cancer</subject><subject>Endometriosis</subject><subject>Endometrium</subject><subject>Fibroids</subject><subject>Gene Function</subject><subject>Genetic analysis</subject><subject>Genetic aspects</subject><subject>Genetic relationship</subject><subject>Genome-wide association studies</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Gynecological diseases</subject><subject>Gynecology</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Human Genetics</subject><subject>Metabolic Diseases</subject><subject>Molecular Medicine</subject><subject>Oncology, Experimental</subject><subject>Original Investigation</subject><subject>Polycystic ovary syndrome</subject><subject>Reproductive system</subject><subject>Risk factors</subject><subject>Stein-Leventhal syndrome</subject><subject>Uterine cancer</subject><subject>Uterine fibroids</subject><subject>Uterus</subject><subject>Wnt protein</subject><issn>0340-6717</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kl9rFDEUxQdRcK1-AZ8Cvig4a_7MTGYeS9FaKApa8TFkkzvT1Gyy5mbU_YJ-LrO7hbpSJITAze-cQ8KpqueMLhml8g1S2oihppyVLRiv6YNqwRrBa8apeFgtqGho3UkmH1dPEG8oZe3A20X1-xwCZGeIDtpvEZDEkUzbACb6ODmjPbEOQSMQZyFkN27JdCtJ4HV2MeC12yBZQf4JEMicIbkAZHSrFJ3F4mwJBBvXkJMrfkYHA-n1fq5JiD_A33N_l-LwW4maShDRmeRrIF8_XDWEbUS3ZJz4aGZ8Wj0atUd4dnueVF_evb06e19ffjy_ODu9rE0zyFwD72UneWN6zYa-lSutG7tiXAvaddbqnpumYxKgUL1ox14aLq1uGbd0NY5CnFQvD76bFL_PgFmtHRrwXgeIMyretnwYGk77gr74B72Jcyq_vKfkwAQf_qIm7UG5MMactNmZqtNOUim7vqGFWt5DlWVh7UwMMLoyPxK8OhIUJsOvPOkZUV18_nTM8gNrUkRMMKpNcmudtopRtWuXOrRLlXapfbvUTiQOIixwmCDdve4_qj9LJtJt</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Kho, Pik Fang</creator><creator>Mortlock, Sally</creator><creator>Rogers, Peter A. 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W.</au><au>Nyholt, Dale R.</au><au>Montgomery, Grant W.</au><au>Spurdle, Amanda B.</au><au>Glubb, Dylan M.</au><au>O’Mara, Tracy A.</au><aucorp>Endometrial Cancer Association Consortium</aucorp><aucorp>International Endometriosis Genetics Consortium</aucorp><aucorp>iPSYCH-SSI-Broad Groupw</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus</atitle><jtitle>Human genetics</jtitle><stitle>Hum Genet</stitle><date>2021-09-01</date><risdate>2021</risdate><volume>140</volume><issue>9</issue><spage>1353</spage><epage>1365</epage><pages>1353-1365</pages><issn>0340-6717</issn><eissn>1432-1203</eissn><abstract>Endometriosis, polycystic ovary syndrome (PCOS) and uterine fibroids have been proposed as endometrial cancer risk factors; however, disentangling their relationships with endometrial cancer is complicated due to shared risk factors and comorbidities. Using genome-wide association study (GWAS) data, we explored the relationships between these non-cancerous gynecological diseases and endometrial cancer risk by assessing genetic correlation, causal relationships and shared risk loci. We found significant genetic correlation between endometrial cancer and PCOS, and uterine fibroids. Adjustment for genetically predicted body mass index (a risk factor for PCOS, uterine fibroids and endometrial cancer) substantially attenuated the genetic correlation between endometrial cancer and PCOS but did not affect the correlation with uterine fibroids. Mendelian randomization analyses suggested a causal relationship between only uterine fibroids and endometrial cancer. Gene-based analyses revealed risk regions shared between endometrial cancer and endometriosis, and uterine fibroids. Multi-trait GWAS analysis of endometrial cancer and the genetically correlated gynecological diseases identified a novel genome-wide significant endometrial cancer risk locus at 1p36.12, which replicated in an independent endometrial cancer dataset. Interrogation of functional genomic data at 1p36.12 revealed biologically relevant genes, including
WNT4
which is necessary for the development of the female reproductive system. In summary, our study provides genetic evidence for a causal relationship between uterine fibroids and endometrial cancer. It further provides evidence that the comorbidity of endometrial cancer, PCOS and uterine fibroids may partly be due to shared genetic architecture. Notably, this shared architecture has revealed a novel genome-wide risk locus for endometrial cancer.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00439-021-02312-0</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-5436-3232</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-6717 |
| ispartof | Human genetics, 2021-09, Vol.140 (9), p.1353-1365 |
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| language | eng |
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| source | SpringerNature Journals |
| subjects | Biomedical and Life Sciences Biomedicine Body mass index Cancer Chromosome 1 Comorbidity Endometrial cancer Endometriosis Endometrium Fibroids Gene Function Genetic analysis Genetic aspects Genetic relationship Genome-wide association studies Genomes Genomics Gynecological diseases Gynecology Health aspects Health risk assessment Human Genetics Metabolic Diseases Molecular Medicine Oncology, Experimental Original Investigation Polycystic ovary syndrome Reproductive system Risk factors Stein-Leventhal syndrome Uterine cancer Uterine fibroids Uterus Wnt protein |
| title | Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus |
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