Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway

Diabetes-associated affective disorders are of wide concern, and oxidative stress plays a vital role in the pathological process. This study was to investigate the cerebroprotective effects of hesperetin against anxious and depressive disorders caused by diabetes, exploring the potential mechanisms...

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Veröffentlicht in:	Metabolic brain disease 2021-10, Vol.36 (7), p.1969-1983
Hauptverfasser:	Zhu, Xia, Zhang, Yu-Meng, Zhang, Meng-Ya, Chen, Ya-Jing, Liu, Yao-Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	Affective disorders Animals Antidepressants Anxiety Anxiety - drug therapy Anxiety - etiology Biochemistry Biomedical and Life Sciences Biomedicine Brain Cytoplasm Depression - drug therapy Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Field tests Gene expression Glucose Glycogen Synthase Kinase 3 beta - metabolism Hesperidin Mental depression Mental disorders Metabolic Diseases mRNA Neurology Neuroprotection Neurosciences NF-E2-Related Factor 2 - metabolism Oncology Open-field behavior Original Article Oxidative Stress Phosphorylation Protein expression Protein kinase C Proteins Rats Rodents Streptozocin γ-Glutamylcysteine
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