Norcantharidin combined with paclitaxel induces endoplasmic reticulum stress mediated apoptotic effect in prostate cancer cells by targeting SIRT7 expression

Prostate cancer (PCa), an extremely common malignancy in males, is the most prevalent disease in several countries. Norcantharidin (NCTD) has antiproliferation, antimetastasis, apoptosis, and autophagy effects in various tumor cells. Nevertheless, the antitumor effect of NCTD combined with paclitaxe...

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Veröffentlicht in:	Environmental toxicology 2021-11, Vol.36 (11), p.2206-2216
Hauptverfasser:	Wu, Min‐Hua, Hui, Su‐Chun, Chen, Yong‐Syuan, Chiou, Hui‐Ling, Lin, Ching‐Yi, Lee, Chien‐Hsing, Hsieh, Yi‐Hsien
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V Anticancer properties Antitumor activity Antitumour agents Apoptosis Assaying Autophagy Cancer Cell cycle Cell death Cell viability Colonies Deoxyribonucleic acid DNA Endoplasmic reticulum endoplasmic reticulum stress Evaluation Gene expression Malignancy Membrane potential Mitochondria Neoplasms Norcantharidin Paclitaxel Phagocytosis Poly(ADP-ribose) polymerase Prostate cancer prostate cancer cells Proteins Staining Stress Transfection Tumor cells Western blotting
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