Pectoralis muscle area and its association with indices of disease severity in interstitial lung disease
The pathophysiology of interstitial lung disease (ILD) impacts body composition, whereby ILD severity is linked to lower lean mass. To determine i) if pectoralis muscle area (PMA) is a surrogate for whole-body lean mass in ILD, ii) whether PMA is associated with ILD severity, and iii) if the longitu...
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| Veröffentlicht in: | Respiratory medicine 2021-09, Vol.186, p.106539-106539, Article 106539 |
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| creator | Molgat-Seon, Yannick Guler, Sabina A. Peters, Carli M. Vasilescu, Dragoş M. Puyat, Joseph H. Coxson, Harvey O. Ryerson, Christopher J. Guenette, Jordan A. |
| description | The pathophysiology of interstitial lung disease (ILD) impacts body composition, whereby ILD severity is linked to lower lean mass.
To determine i) if pectoralis muscle area (PMA) is a surrogate for whole-body lean mass in ILD, ii) whether PMA is associated with ILD severity, and iii) if the longitudinal change in PMA is associated with pulmonary function and mortality in ILD.
Patients with ILD (n = 164) were analyzed retrospectively. PMA was quantified from a chest computed tomography scan. Peripheral oxygen saturation (SpO2), 6-min walk distance (6MWD), and pulmonary function were obtained as part of routine clinical care. Dyspnea and quality of life were assessed using the UCSD Shortness of Breath Questionnaire and European Quality of Life 5 Dimensions questionnaire, respectively.
PMA was associated with whole-body lean mass (p |
| doi_str_mv | 10.1016/j.rmed.2021.106539 |
| format | Article |
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To determine i) if pectoralis muscle area (PMA) is a surrogate for whole-body lean mass in ILD, ii) whether PMA is associated with ILD severity, and iii) if the longitudinal change in PMA is associated with pulmonary function and mortality in ILD.
Patients with ILD (n = 164) were analyzed retrospectively. PMA was quantified from a chest computed tomography scan. Peripheral oxygen saturation (SpO2), 6-min walk distance (6MWD), and pulmonary function were obtained as part of routine clinical care. Dyspnea and quality of life were assessed using the UCSD Shortness of Breath Questionnaire and European Quality of Life 5 Dimensions questionnaire, respectively.
PMA was associated with whole-body lean mass (p < 0.001). After adjusting for age, sex, height, body mass, and prednisone status, PMA was associated with %-predicted forced vital capacity (FVC), %-predicted diffusion capacity (DLCO), resting and exertional SpO2, and dyspnea (all p < 0.05), but not forced expiratory volume in 1 s (FEV1), FEV1/FVC, 6MWD, or quality of life (all p > 0.05). The annual negative PMA slope was associated with annual negative slopes in FVC, FEV1, and DLCO (all p < 0.05), but not FEV1/FVC (p = 0.46). Annual slope in PMA was associated with all-cause mortality (hazard ratio = −0.80, 95% CI:0.889–0.959; p < 0.001).
In patients with ILD, PMA is a suitable surrogate for whole-body lean mass. A lower PMA is associated with indices of ILD severity, which supports the notion that ILD progression may involve sarcopenia.
•Pectoralis muscle area (PMA) is correlated with muscle mass in patients with interstitial lung disease (ILD).•A lower PMA is associated with indices of ILD severity.•Declines in PMA are associated with ILD-related changes in pulmonary function and mortality.•PMA could be used to evaluate ILD prognosis.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2021.106539</identifier><identifier>PMID: 34271524</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Body Composition ; Disease Progression ; Dyspnea ; Hypersensitivity pneumonitis ; Idiopathic pulmonary fibrosis ; Lung Diseases, Interstitial - complications ; Lung Diseases, Interstitial - diagnosis ; Lung Diseases, Interstitial - mortality ; Lung Diseases, Interstitial - physiopathology ; Oximetry ; Patient Acuity ; Pectoralis Muscles - diagnostic imaging ; Pectoralis Muscles - pathology ; Pectoralis Muscles - physiopathology ; Quality of Life ; Respiratory Function Tests ; Retrospective Studies ; Sarcopenia ; Sarcopenia - etiology ; Skeletal muscle dysfunction ; Thinness ; Tomography, X-Ray Computed ; Walk Test</subject><ispartof>Respiratory medicine, 2021-09, Vol.186, p.106539-106539, Article 106539</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-59fd124ea024442d695ac5bb402470cc4d98a770f912b047130c2e8d06a4e18d3</citedby><cites>FETCH-LOGICAL-c400t-59fd124ea024442d695ac5bb402470cc4d98a770f912b047130c2e8d06a4e18d3</cites><orcidid>0000-0003-1660-9032 ; 0000-0003-4021-4540</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rmed.2021.106539$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34271524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Molgat-Seon, Yannick</creatorcontrib><creatorcontrib>Guler, Sabina A.</creatorcontrib><creatorcontrib>Peters, Carli M.</creatorcontrib><creatorcontrib>Vasilescu, Dragoş M.</creatorcontrib><creatorcontrib>Puyat, Joseph H.</creatorcontrib><creatorcontrib>Coxson, Harvey O.</creatorcontrib><creatorcontrib>Ryerson, Christopher J.</creatorcontrib><creatorcontrib>Guenette, Jordan A.</creatorcontrib><title>Pectoralis muscle area and its association with indices of disease severity in interstitial lung disease</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>The pathophysiology of interstitial lung disease (ILD) impacts body composition, whereby ILD severity is linked to lower lean mass.
To determine i) if pectoralis muscle area (PMA) is a surrogate for whole-body lean mass in ILD, ii) whether PMA is associated with ILD severity, and iii) if the longitudinal change in PMA is associated with pulmonary function and mortality in ILD.
Patients with ILD (n = 164) were analyzed retrospectively. PMA was quantified from a chest computed tomography scan. Peripheral oxygen saturation (SpO2), 6-min walk distance (6MWD), and pulmonary function were obtained as part of routine clinical care. Dyspnea and quality of life were assessed using the UCSD Shortness of Breath Questionnaire and European Quality of Life 5 Dimensions questionnaire, respectively.
PMA was associated with whole-body lean mass (p < 0.001). After adjusting for age, sex, height, body mass, and prednisone status, PMA was associated with %-predicted forced vital capacity (FVC), %-predicted diffusion capacity (DLCO), resting and exertional SpO2, and dyspnea (all p < 0.05), but not forced expiratory volume in 1 s (FEV1), FEV1/FVC, 6MWD, or quality of life (all p > 0.05). The annual negative PMA slope was associated with annual negative slopes in FVC, FEV1, and DLCO (all p < 0.05), but not FEV1/FVC (p = 0.46). Annual slope in PMA was associated with all-cause mortality (hazard ratio = −0.80, 95% CI:0.889–0.959; p < 0.001).
In patients with ILD, PMA is a suitable surrogate for whole-body lean mass. A lower PMA is associated with indices of ILD severity, which supports the notion that ILD progression may involve sarcopenia.
•Pectoralis muscle area (PMA) is correlated with muscle mass in patients with interstitial lung disease (ILD).•A lower PMA is associated with indices of ILD severity.•Declines in PMA are associated with ILD-related changes in pulmonary function and mortality.•PMA could be used to evaluate ILD prognosis.</description><subject>Body Composition</subject><subject>Disease Progression</subject><subject>Dyspnea</subject><subject>Hypersensitivity pneumonitis</subject><subject>Idiopathic pulmonary fibrosis</subject><subject>Lung Diseases, Interstitial - complications</subject><subject>Lung Diseases, Interstitial - diagnosis</subject><subject>Lung Diseases, Interstitial - mortality</subject><subject>Lung Diseases, Interstitial - physiopathology</subject><subject>Oximetry</subject><subject>Patient Acuity</subject><subject>Pectoralis Muscles - diagnostic imaging</subject><subject>Pectoralis Muscles - pathology</subject><subject>Pectoralis Muscles - physiopathology</subject><subject>Quality of Life</subject><subject>Respiratory Function Tests</subject><subject>Retrospective Studies</subject><subject>Sarcopenia</subject><subject>Sarcopenia - etiology</subject><subject>Skeletal muscle dysfunction</subject><subject>Thinness</subject><subject>Tomography, X-Ray Computed</subject><subject>Walk Test</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFKJDEQhsPiso66L7CHJce99FhJV7qnwcsirgqCHtZzyCTVa4aebk2lFd9-M4xzFQpCpb76oT4hfihYKlDN-WaZthSWGrQqH42puy9ioUytqxoaPBIL6AxWjVLqWJwwbwCgQ4Rv4rhG3SqjcSGeHsjnKbkhstzO7AeSLpGTbgwyZpaOefLR5TiN8i3mJxnHED2xnHoZIpNjkkyvlGJ-L7NSmRLnmKMb5DCP_w7Umfjau4Hp-8d7Kh7_XP29vKnu7q9vL3_fVR4BcmW6PiiN5EAjog5NZ5w36zWWvgXvMXQr17bQd0qvAVtVg9e0CtA4JLUK9an4tc99TtPLTJztNrKnYXAjTTNbbYzuVgYNFlTvUZ8m5kS9fU5x69K7VWB3hu3G7gzbnWG7N1yWfn7kz-vd7LByUFqAiz1A5crXSMmyjzR6CjEV1zZM8bP8_4aUjS0</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Molgat-Seon, Yannick</creator><creator>Guler, Sabina A.</creator><creator>Peters, Carli M.</creator><creator>Vasilescu, Dragoş M.</creator><creator>Puyat, Joseph H.</creator><creator>Coxson, Harvey O.</creator><creator>Ryerson, Christopher J.</creator><creator>Guenette, Jordan A.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1660-9032</orcidid><orcidid>https://orcid.org/0000-0003-4021-4540</orcidid></search><sort><creationdate>202109</creationdate><title>Pectoralis muscle area and its association with indices of disease severity in interstitial lung disease</title><author>Molgat-Seon, Yannick ; Guler, Sabina A. ; Peters, Carli M. ; Vasilescu, Dragoş M. ; Puyat, Joseph H. ; Coxson, Harvey O. ; Ryerson, Christopher J. ; Guenette, Jordan A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-59fd124ea024442d695ac5bb402470cc4d98a770f912b047130c2e8d06a4e18d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Body Composition</topic><topic>Disease Progression</topic><topic>Dyspnea</topic><topic>Hypersensitivity pneumonitis</topic><topic>Idiopathic pulmonary fibrosis</topic><topic>Lung Diseases, Interstitial - complications</topic><topic>Lung Diseases, Interstitial - diagnosis</topic><topic>Lung Diseases, Interstitial - mortality</topic><topic>Lung Diseases, Interstitial - physiopathology</topic><topic>Oximetry</topic><topic>Patient Acuity</topic><topic>Pectoralis Muscles - diagnostic imaging</topic><topic>Pectoralis Muscles - pathology</topic><topic>Pectoralis Muscles - physiopathology</topic><topic>Quality of Life</topic><topic>Respiratory Function Tests</topic><topic>Retrospective Studies</topic><topic>Sarcopenia</topic><topic>Sarcopenia - etiology</topic><topic>Skeletal muscle dysfunction</topic><topic>Thinness</topic><topic>Tomography, X-Ray Computed</topic><topic>Walk Test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Molgat-Seon, Yannick</creatorcontrib><creatorcontrib>Guler, Sabina A.</creatorcontrib><creatorcontrib>Peters, Carli M.</creatorcontrib><creatorcontrib>Vasilescu, Dragoş M.</creatorcontrib><creatorcontrib>Puyat, Joseph H.</creatorcontrib><creatorcontrib>Coxson, Harvey O.</creatorcontrib><creatorcontrib>Ryerson, Christopher J.</creatorcontrib><creatorcontrib>Guenette, Jordan A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Molgat-Seon, Yannick</au><au>Guler, Sabina A.</au><au>Peters, Carli M.</au><au>Vasilescu, Dragoş M.</au><au>Puyat, Joseph H.</au><au>Coxson, Harvey O.</au><au>Ryerson, Christopher J.</au><au>Guenette, Jordan A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pectoralis muscle area and its association with indices of disease severity in interstitial lung disease</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2021-09</date><risdate>2021</risdate><volume>186</volume><spage>106539</spage><epage>106539</epage><pages>106539-106539</pages><artnum>106539</artnum><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>The pathophysiology of interstitial lung disease (ILD) impacts body composition, whereby ILD severity is linked to lower lean mass.
To determine i) if pectoralis muscle area (PMA) is a surrogate for whole-body lean mass in ILD, ii) whether PMA is associated with ILD severity, and iii) if the longitudinal change in PMA is associated with pulmonary function and mortality in ILD.
Patients with ILD (n = 164) were analyzed retrospectively. PMA was quantified from a chest computed tomography scan. Peripheral oxygen saturation (SpO2), 6-min walk distance (6MWD), and pulmonary function were obtained as part of routine clinical care. Dyspnea and quality of life were assessed using the UCSD Shortness of Breath Questionnaire and European Quality of Life 5 Dimensions questionnaire, respectively.
PMA was associated with whole-body lean mass (p < 0.001). After adjusting for age, sex, height, body mass, and prednisone status, PMA was associated with %-predicted forced vital capacity (FVC), %-predicted diffusion capacity (DLCO), resting and exertional SpO2, and dyspnea (all p < 0.05), but not forced expiratory volume in 1 s (FEV1), FEV1/FVC, 6MWD, or quality of life (all p > 0.05). The annual negative PMA slope was associated with annual negative slopes in FVC, FEV1, and DLCO (all p < 0.05), but not FEV1/FVC (p = 0.46). Annual slope in PMA was associated with all-cause mortality (hazard ratio = −0.80, 95% CI:0.889–0.959; p < 0.001).
In patients with ILD, PMA is a suitable surrogate for whole-body lean mass. A lower PMA is associated with indices of ILD severity, which supports the notion that ILD progression may involve sarcopenia.
•Pectoralis muscle area (PMA) is correlated with muscle mass in patients with interstitial lung disease (ILD).•A lower PMA is associated with indices of ILD severity.•Declines in PMA are associated with ILD-related changes in pulmonary function and mortality.•PMA could be used to evaluate ILD prognosis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>34271524</pmid><doi>10.1016/j.rmed.2021.106539</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-1660-9032</orcidid><orcidid>https://orcid.org/0000-0003-4021-4540</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Body Composition Disease Progression Dyspnea Hypersensitivity pneumonitis Idiopathic pulmonary fibrosis Lung Diseases, Interstitial - complications Lung Diseases, Interstitial - diagnosis Lung Diseases, Interstitial - mortality Lung Diseases, Interstitial - physiopathology Oximetry Patient Acuity Pectoralis Muscles - diagnostic imaging Pectoralis Muscles - pathology Pectoralis Muscles - physiopathology Quality of Life Respiratory Function Tests Retrospective Studies Sarcopenia Sarcopenia - etiology Skeletal muscle dysfunction Thinness Tomography, X-Ray Computed Walk Test |
| title | Pectoralis muscle area and its association with indices of disease severity in interstitial lung disease |
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