Inhibitory activities of 20(R, S)-protopanaxatriol against epidermal growth factor receptor tyrosine kinase

As major metabolites of protopanaxatriol-type ginsenosides, 20(R, S)-protopanaxatriol [20(R, S)-PPT] display multiple bioactivities. This work aimed to investigate the inhibitory activities of 20(R, S)-PPT against epidermal growth factor receptor tyrosine kinase and the potential mechanism. 20(R, S)...

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Veröffentlicht in:	Food and chemical toxicology 2021-09, Vol.155, p.112411-112411, Article 112411
Hauptverfasser:	Zhao, Jingqi, Zhang, Tiehua, Liang, Yuan, Zou, Haoyang, Zhang, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	20(R, S)-protopanaxatriol [20(R, S)-PPT] Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Cell Proliferation - drug effects Epidermal growth factor receptor (EGFR) ErbB Receptors - antagonists & inhibitors ErbB Receptors - metabolism G1 Phase Cell Cycle Checkpoints - drug effects Hep G2 Cells Humans Mitogen-activated protein kinase (MAPK) Molecular Docking Simulation Molecular Dynamics Simulation Protein Kinase Inhibitors - metabolism Protein Kinase Inhibitors - pharmacology Sapogenins - metabolism Sapogenins - pharmacology Stereoisomerism Tyrosine kinase inhibitors (TKIs)
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