ARID1A mutation/ARID1A loss is associated with a high immunogenic profile in clear cell ovarian cancer

ARID1A mutation is frequently found in clear cell ovarian cancer (CCC) and endometrioid ovarian cancer (EC). Anti-PD-1 monotherapy has been found to have limited efficacy in epithelial ovarian cancer; however, anti-PD-1 therapy showed significant clinical benefit in some CCC. We sought to define the...

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Veröffentlicht in:	Gynecologic oncology 2021-09, Vol.162 (3), p.679-685
Hauptverfasser:	Kuroda, Yuka, Chiyoda, Tatsuyuki, Kawaida, Miho, Nakamura, Kohei, Aimono, Eriko, Yoshimura, Takuma, Takahashi, Mio, Saotome, Keiko, Yoshihama, Tomoko, Iwasa, Naomi, Sakai, Kensuke, Yamagami, Wataru, Nishihara, Hiroshi, Aoki, Daisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	ARID1A AT-rich interactive domain 1A Biomarkers, Tumor - genetics Carcinoma, Ovarian Epithelial - genetics Carcinoma, Ovarian Epithelial - immunology Cystadenocarcinoma, Serous - genetics Cystadenocarcinoma, Serous - immunology DNA-Binding Proteins - metabolism Female Gene Expression Regulation, Neoplastic Humans Immune therapy Immunotherapy Mutation Neoplasms, Cystic, Mucinous, and Serous - genetics Neoplasms, Cystic, Mucinous, and Serous - immunology Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - immunology PD-L1 Transcription Factors - metabolism
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