Negative-to-Positive Lymph Node Ratio as an Independent Prognostic Factor for Gastric Adenocarcinoma
To investigate the association between the ratio of negative/positive lymph nodes (RNP) and other clinic pathological parameters. Descriptive study. Faculty of Medicine, Cumhuriyet University, Sivas, Turkey, from February 2008 to December 2019. Consecutive 119 patients with gastric adenocarcinoma,...
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| Veröffentlicht in: | Journal of the College of Physicians and Surgeons--Pakistan 2021-07, Vol.31 (7), p.805-810 |
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| container_title | Journal of the College of Physicians and Surgeons--Pakistan |
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| creator | Alakus, Huseyin Kaya, Mustafa Mollaoglu, Murat Can Göksu, Mustafa Ozer, Hatice Karadayi, Kursat |
| description | To investigate the association between the ratio of negative/positive lymph nodes (RNP) and other clinic pathological parameters.
Descriptive study.
Faculty of Medicine, Cumhuriyet University, Sivas, Turkey, from February 2008 to December 2019.
Consecutive 119 patients with gastric adenocarcinoma, who underwent gastrectomy and D2 lymph node dissection, were included. RNP, other clinicopathological parameters such as tumour grade, type and lymphovascular invasion (LVI) were analysed, as their prognostic impact was investigated.
RNP was an independent prognostic factor for overall survival (p = 0.003) and was significantly associated with poor survival (p |
| doi_str_mv | 10.29271/jcpsp.2021.07.805 |
| format | Article |
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Descriptive study.
Faculty of Medicine, Cumhuriyet University, Sivas, Turkey, from February 2008 to December 2019.
Consecutive 119 patients with gastric adenocarcinoma, who underwent gastrectomy and D2 lymph node dissection, were included. RNP, other clinicopathological parameters such as tumour grade, type and lymphovascular invasion (LVI) were analysed, as their prognostic impact was investigated.
RNP was an independent prognostic factor for overall survival (p = 0.003) and was significantly associated with poor survival (p <0.001). Advanced pathologic T and N stage, presence of perineural invasion (PNI), presence of LVI, high tumour grade, and diffuse-type as per Louren's classification, and the number of the negative lymph nodes were also significantly associated with poor survival (all p <0.05). Although pathologic N stage (p <0.01), PNI (p <0.01), LVI (p <0.01), tumour type as per Louren's classification (p <0.01), tumour grade (p <0.01) and the number of negative lymph nodes (p <0.01) were significantly associated with overall survival in univariate analyses; only gender (p = 0.025), gastrectomy type (p = 0.037), PNI (p = 0.028), tumour type (p = 0.006), and number of negative lymph nodes (p = 0.003) were meaningfully associated with survival in a multivariate analysis.
The ratio of negative/positive lymph nodes can be used as an independent prognostic marker in patients with gastric cancer, who undergo curative resection, as an alternative prognostic marker to the pathologic N stage. Key Words: Stomach neoplasms, Lymph node ratio, Prognosis, Gastrectomy, Lymph nodes.]]></description><identifier>ISSN: 1022-386X</identifier><identifier>EISSN: 1681-7168</identifier><identifier>DOI: 10.29271/jcpsp.2021.07.805</identifier><identifier>PMID: 34271780</identifier><language>eng</language><publisher>Pakistan: College of Physicians and Surgeons Pakistan</publisher><subject>Adenocarcinoma - surgery ; Care and treatment ; Gastrectomy ; Humans ; Lymph Node Excision ; Lymph Node Ratio ; Lymph nodes ; Lymph Nodes - pathology ; Neoplasm Invasiveness ; Neoplasm Staging ; Patient outcomes ; Prognosis ; Retrospective Studies ; Stomach cancer ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Surgery ; Survival Rate ; Turkey - epidemiology</subject><ispartof>Journal of the College of Physicians and Surgeons--Pakistan, 2021-07, Vol.31 (7), p.805-810</ispartof><rights>COPYRIGHT 2021 College of Physicians and Surgeons Pakistan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-19b323fb6354b5e243e6dbeae9613676c98668d5f6104efe167bfccf16494d5b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34271780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alakus, Huseyin</creatorcontrib><creatorcontrib>Kaya, Mustafa</creatorcontrib><creatorcontrib>Mollaoglu, Murat Can</creatorcontrib><creatorcontrib>Göksu, Mustafa</creatorcontrib><creatorcontrib>Ozer, Hatice</creatorcontrib><creatorcontrib>Karadayi, Kursat</creatorcontrib><title>Negative-to-Positive Lymph Node Ratio as an Independent Prognostic Factor for Gastric Adenocarcinoma</title><title>Journal of the College of Physicians and Surgeons--Pakistan</title><addtitle>J Coll Physicians Surg Pak</addtitle><description><![CDATA[To investigate the association between the ratio of negative/positive lymph nodes (RNP) and other clinic pathological parameters.
Descriptive study.
Faculty of Medicine, Cumhuriyet University, Sivas, Turkey, from February 2008 to December 2019.
Consecutive 119 patients with gastric adenocarcinoma, who underwent gastrectomy and D2 lymph node dissection, were included. RNP, other clinicopathological parameters such as tumour grade, type and lymphovascular invasion (LVI) were analysed, as their prognostic impact was investigated.
RNP was an independent prognostic factor for overall survival (p = 0.003) and was significantly associated with poor survival (p <0.001). Advanced pathologic T and N stage, presence of perineural invasion (PNI), presence of LVI, high tumour grade, and diffuse-type as per Louren's classification, and the number of the negative lymph nodes were also significantly associated with poor survival (all p <0.05). Although pathologic N stage (p <0.01), PNI (p <0.01), LVI (p <0.01), tumour type as per Louren's classification (p <0.01), tumour grade (p <0.01) and the number of negative lymph nodes (p <0.01) were significantly associated with overall survival in univariate analyses; only gender (p = 0.025), gastrectomy type (p = 0.037), PNI (p = 0.028), tumour type (p = 0.006), and number of negative lymph nodes (p = 0.003) were meaningfully associated with survival in a multivariate analysis.
The ratio of negative/positive lymph nodes can be used as an independent prognostic marker in patients with gastric cancer, who undergo curative resection, as an alternative prognostic marker to the pathologic N stage. Key Words: Stomach neoplasms, Lymph node ratio, Prognosis, Gastrectomy, Lymph nodes.]]></description><subject>Adenocarcinoma - surgery</subject><subject>Care and treatment</subject><subject>Gastrectomy</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Lymph Node Ratio</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - pathology</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Patient outcomes</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Turkey - epidemiology</subject><issn>1022-386X</issn><issn>1681-7168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkV1rHCEUhofSkq_mD_SiCL3pzUz81rlcQpIGliSUFnonjnPcGnbGqbqF_Pu62aRQKOLxcHweEd6m-UBwR3uqyMWjW_LSUUxJh1WnsXjTnBCpSatqfVt7TGnLtPxx3Jzm_IgxE0Tro-aY8aorjU-a8Q42toTf0JbYPsQc9j1aP03LT3QXR0Bf621ENiM7o9t5hAVqmQt6SHEzx1yCQ9fWlZiQr_vG5pLqaFWZ6GxyYY6Tfd-883ab4fzlPGu-X199u_zSru9vbi9X69ZxwktL-oFR5gfJBB8EUM5AjgNY6CVhUknXayn1KLwkmIMHItXgnfNE8p6PYmBnzefDu0uKv3aQi5lCdrDd2hniLhsqBO0111pV9NMB3dgtmDD7WJJ1e9yspMKcKCZ0pbr_UHWNMAUXZ_Chzv8R6EFwKeacwJslhcmmJ0OweQ7NPIdm9qEZrEwNrUofX769GyYY_yqvKbE_WqiS-g</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Alakus, Huseyin</creator><creator>Kaya, Mustafa</creator><creator>Mollaoglu, Murat Can</creator><creator>Göksu, Mustafa</creator><creator>Ozer, Hatice</creator><creator>Karadayi, Kursat</creator><general>College of Physicians and Surgeons Pakistan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202107</creationdate><title>Negative-to-Positive Lymph Node Ratio as an Independent Prognostic Factor for Gastric Adenocarcinoma</title><author>Alakus, Huseyin ; Kaya, Mustafa ; Mollaoglu, Murat Can ; Göksu, Mustafa ; Ozer, Hatice ; Karadayi, Kursat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-19b323fb6354b5e243e6dbeae9613676c98668d5f6104efe167bfccf16494d5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenocarcinoma - surgery</topic><topic>Care and treatment</topic><topic>Gastrectomy</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Lymph Node Ratio</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - pathology</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Patient outcomes</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alakus, Huseyin</creatorcontrib><creatorcontrib>Kaya, Mustafa</creatorcontrib><creatorcontrib>Mollaoglu, Murat Can</creatorcontrib><creatorcontrib>Göksu, Mustafa</creatorcontrib><creatorcontrib>Ozer, Hatice</creatorcontrib><creatorcontrib>Karadayi, Kursat</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alakus, Huseyin</au><au>Kaya, Mustafa</au><au>Mollaoglu, Murat Can</au><au>Göksu, Mustafa</au><au>Ozer, Hatice</au><au>Karadayi, Kursat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Negative-to-Positive Lymph Node Ratio as an Independent Prognostic Factor for Gastric Adenocarcinoma</atitle><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle><addtitle>J Coll Physicians Surg Pak</addtitle><date>2021-07</date><risdate>2021</risdate><volume>31</volume><issue>7</issue><spage>805</spage><epage>810</epage><pages>805-810</pages><issn>1022-386X</issn><eissn>1681-7168</eissn><abstract><![CDATA[To investigate the association between the ratio of negative/positive lymph nodes (RNP) and other clinic pathological parameters.
Descriptive study.
Faculty of Medicine, Cumhuriyet University, Sivas, Turkey, from February 2008 to December 2019.
Consecutive 119 patients with gastric adenocarcinoma, who underwent gastrectomy and D2 lymph node dissection, were included. RNP, other clinicopathological parameters such as tumour grade, type and lymphovascular invasion (LVI) were analysed, as their prognostic impact was investigated.
RNP was an independent prognostic factor for overall survival (p = 0.003) and was significantly associated with poor survival (p <0.001). Advanced pathologic T and N stage, presence of perineural invasion (PNI), presence of LVI, high tumour grade, and diffuse-type as per Louren's classification, and the number of the negative lymph nodes were also significantly associated with poor survival (all p <0.05). Although pathologic N stage (p <0.01), PNI (p <0.01), LVI (p <0.01), tumour type as per Louren's classification (p <0.01), tumour grade (p <0.01) and the number of negative lymph nodes (p <0.01) were significantly associated with overall survival in univariate analyses; only gender (p = 0.025), gastrectomy type (p = 0.037), PNI (p = 0.028), tumour type (p = 0.006), and number of negative lymph nodes (p = 0.003) were meaningfully associated with survival in a multivariate analysis.
The ratio of negative/positive lymph nodes can be used as an independent prognostic marker in patients with gastric cancer, who undergo curative resection, as an alternative prognostic marker to the pathologic N stage. Key Words: Stomach neoplasms, Lymph node ratio, Prognosis, Gastrectomy, Lymph nodes.]]></abstract><cop>Pakistan</cop><pub>College of Physicians and Surgeons Pakistan</pub><pmid>34271780</pmid><doi>10.29271/jcpsp.2021.07.805</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - surgery Care and treatment Gastrectomy Humans Lymph Node Excision Lymph Node Ratio Lymph nodes Lymph Nodes - pathology Neoplasm Invasiveness Neoplasm Staging Patient outcomes Prognosis Retrospective Studies Stomach cancer Stomach Neoplasms - pathology Stomach Neoplasms - surgery Surgery Survival Rate Turkey - epidemiology |
| title | Negative-to-Positive Lymph Node Ratio as an Independent Prognostic Factor for Gastric Adenocarcinoma |
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