Brief Report: Polymorphisms in TNF-α/TNFR1 Pathway Genes Are Associated With CD4+ T-Cell Recovery in HIV-1–Infected Individuals on Antiretroviral Therapy

Antiretroviral therapy (ART) is an important hallmark of HIV-1 treatment, enabling viral load suppression to undetectable levels and CD4+ T-cell recovery. However, some individuals do not recover the CD4+ T-cell count to normal levels, despite viral suppression. We hypothesize that variation in gene...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2021-11, Vol.88 (3), p.322-327
Hauptverfasser:	Celerino da Silva, Ronaldo, Alves, Neyla M. Pereira, Gondim Silva, Maria L., Agrelli, Almerinda, Coelho, Antonio V. Campos, Guimarães, Rafael L., Arraes, Luiz C., Crovella, Sergio, Brandão, Lucas A. Cavalcanti
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active - adverse effects Apoptosis CD4 antigen CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism Drug therapy Epidemiology Failure analysis Genes HIV HIV Infections - drug therapy HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV Seropositivity HIV-1 - genetics HIV-1 - isolation & purification Human immunodeficiency virus Humans Immunology Lymphocytes T Male Mathematical analysis Middle Aged Multivariate analysis Nucleotides Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type I - therapeutic use Recovery Risk analysis Risk factors Sexually transmitted diseases Single-nucleotide polymorphism STD Survival analysis Tumor necrosis factor receptors Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-α Viral Load Young Adult Zidovudine
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