Second trimester maternal serum biomarkers and the risk of cerebral palsy
Aims To investigate whether second trimester maternal serum screening (2TMSS) biomarkers are associated with cerebral palsy (CP) and identify CP characteristics associated with abnormal biomarker levels. Method In this retrospective case–control data linkage study, we linked mothers of 129 singleton...
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| Veröffentlicht in: | Prenatal diagnosis 2021-08, Vol.41 (9), p.1101-1110 |
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| creator | Peris, Monique Reid, Susan M. Dobie, Stephen Bonacquisto, Leo Shepherd, Daisy A. Amor, David J. |
| description | Aims
To investigate whether second trimester maternal serum screening (2TMSS) biomarkers are associated with cerebral palsy (CP) and identify CP characteristics associated with abnormal biomarker levels.
Method
In this retrospective case–control data linkage study, we linked mothers of 129 singleton CP cases from a population register to their 2TMSS records and selected 10 singleton pregnancy controls per case (n = 1290). We compared mean and abnormal levels of alpha‐fetoprotein (AFP), beta subunit of human chorionic gonadotrophin (β‐hCG), unconjugated estriol (uE3), and inhibin between cases and controls and within CP subgroups.
Results
Compared to control pregnancies, CP pregnancies had higher mean levels of AFP (1.10 vs. 1.01 multiple of the population median [MoM], p = 0.01) and inhibin (1.10 vs. 0.98 MoM, p ≤ 0.01). CP pregnancies were 2.5 times more likely to be associated with high levels of AFP (OR 2.52 [95% confidence interval [CI] 1.30, 4.65]; p |
| doi_str_mv | 10.1002/pd.6011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_proquest_miscellaneous_2552984093</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2552984093</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3781-c3ed1f7570fea9d1eb9975e47666427f1875f3632b997d5819029249011ed1933</originalsourceid><addsrcrecordid>eNqNkFtLxDAQhYMoul7wH0jBBwVZnSRNkzzKegVBQX0uaTvFatvUpEX235u66yKC4MvMMHxnOHMI2adwSgHYWVecJkDpGplQ0HIKjPF1MgEaZq4E3SLb3r8GUDEtN8kWj5kERfmE3D5ibtsi6l3VoO_RRY0JtTV15NENTZRVtjHuDZ2PzMi9YOQq_xbZMsrRYeYC2Znaz3fJRhk67i37Dnm-unya3Uzv7q9vZ-d305xLRUPFgpZSSCjR6IJiprUUGMskSYKrkiopSp5wNu4LoagGplmsw3dBqDnfIceLu52z70PwnDaVz7GuTYt28CkTgmkVwxd6-At9tcP420glIKRSTATqaEHlznrvsEy7EIZx85RCOqabdkU6phvIg-W9IWuwWHHfcQZALYAPzGzp8wrbHFcYACRSgBRxmIDOqt70lW1ndmj7ID35v_QHXdU4_8tw-nDx5fsTyYCgFA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2560578825</pqid></control><display><type>article</type><title>Second trimester maternal serum biomarkers and the risk of cerebral palsy</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Peris, Monique ; Reid, Susan M. ; Dobie, Stephen ; Bonacquisto, Leo ; Shepherd, Daisy A. ; Amor, David J.</creator><creatorcontrib>Peris, Monique ; Reid, Susan M. ; Dobie, Stephen ; Bonacquisto, Leo ; Shepherd, Daisy A. ; Amor, David J.</creatorcontrib><description>Aims
To investigate whether second trimester maternal serum screening (2TMSS) biomarkers are associated with cerebral palsy (CP) and identify CP characteristics associated with abnormal biomarker levels.
Method
In this retrospective case–control data linkage study, we linked mothers of 129 singleton CP cases from a population register to their 2TMSS records and selected 10 singleton pregnancy controls per case (n = 1290). We compared mean and abnormal levels of alpha‐fetoprotein (AFP), beta subunit of human chorionic gonadotrophin (β‐hCG), unconjugated estriol (uE3), and inhibin between cases and controls and within CP subgroups.
Results
Compared to control pregnancies, CP pregnancies had higher mean levels of AFP (1.10 vs. 1.01 multiple of the population median [MoM], p = 0.01) and inhibin (1.10 vs. 0.98 MoM, p ≤ 0.01). CP pregnancies were 2.5 times more likely to be associated with high levels of AFP (OR 2.52 [95% confidence interval [CI] 1.30, 4.65]; p < 0.01) and 2.6 times for inhibin (OR 2.63 [95% CI 1.37, 4.77]; p < 0.01), and 6.8 times when AFP and inhibin were both elevated (OR 6.75 [95% CI 2.41, 18.94]; p < 0.01). In CP cases, high AFP and high inhibin levels were associated with preterm birth and low birthweight.
Interpretation
Abnormal second‐trimester biomarker levels suggest abnormal placentation plays a role in the causal pathway of some CP cases.
Key points
What is already known about this topic?
Abnormal second‐trimester levels of biomarkers in maternal serum are associated with later cerebral palsy (CP).
Early pregnancy factors have potential importance in causal pathways to CP.
What does this study add?
Causal pathways involving placental dysfunction and genetic syndromes may be implicated.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.6011</identifier><identifier>PMID: 34270813</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject><![CDATA[Adult ; Analysis of Variance ; Biomarkers ; Biomarkers - analysis ; Biomarkers - blood ; Birth weight ; Case-Control Studies ; Cerebral palsy ; Cerebral Palsy - diagnosis ; Cerebral Palsy - epidemiology ; Cerebral Palsy - genetics ; Confidence intervals ; Control data (computers) ; Female ; Genetics & Heredity ; Humans ; Inhibin ; Life Sciences & Biomedicine ; Mothers - statistics & numerical data ; Obstetrics & Gynecology ; Paralysis ; Pituitary (anterior) ; Pregnancy ; Pregnancy Trimester, Second - blood ; Pregnancy Trimester, Second - genetics ; Premature birth ; Prenatal Diagnosis - methods ; Prenatal Diagnosis - standards ; Prenatal Diagnosis - statistics & numerical data ; Retrospective Studies ; Science & Technology ; Subgroups ; Victoria - epidemiology]]></subject><ispartof>Prenatal diagnosis, 2021-08, Vol.41 (9), p.1101-1110</ispartof><rights>2021 John Wiley & Sons Ltd.</rights><rights>2021 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>2</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000675075400001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3781-c3ed1f7570fea9d1eb9975e47666427f1875f3632b997d5819029249011ed1933</citedby><cites>FETCH-LOGICAL-c3781-c3ed1f7570fea9d1eb9975e47666427f1875f3632b997d5819029249011ed1933</cites><orcidid>0000-0001-7191-8511 ; 0000-0001-8540-0473</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.6011$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.6011$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,39265,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34270813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peris, Monique</creatorcontrib><creatorcontrib>Reid, Susan M.</creatorcontrib><creatorcontrib>Dobie, Stephen</creatorcontrib><creatorcontrib>Bonacquisto, Leo</creatorcontrib><creatorcontrib>Shepherd, Daisy A.</creatorcontrib><creatorcontrib>Amor, David J.</creatorcontrib><title>Second trimester maternal serum biomarkers and the risk of cerebral palsy</title><title>Prenatal diagnosis</title><addtitle>PRENATAL DIAG</addtitle><addtitle>Prenat Diagn</addtitle><description>Aims
To investigate whether second trimester maternal serum screening (2TMSS) biomarkers are associated with cerebral palsy (CP) and identify CP characteristics associated with abnormal biomarker levels.
Method
In this retrospective case–control data linkage study, we linked mothers of 129 singleton CP cases from a population register to their 2TMSS records and selected 10 singleton pregnancy controls per case (n = 1290). We compared mean and abnormal levels of alpha‐fetoprotein (AFP), beta subunit of human chorionic gonadotrophin (β‐hCG), unconjugated estriol (uE3), and inhibin between cases and controls and within CP subgroups.
Results
Compared to control pregnancies, CP pregnancies had higher mean levels of AFP (1.10 vs. 1.01 multiple of the population median [MoM], p = 0.01) and inhibin (1.10 vs. 0.98 MoM, p ≤ 0.01). CP pregnancies were 2.5 times more likely to be associated with high levels of AFP (OR 2.52 [95% confidence interval [CI] 1.30, 4.65]; p < 0.01) and 2.6 times for inhibin (OR 2.63 [95% CI 1.37, 4.77]; p < 0.01), and 6.8 times when AFP and inhibin were both elevated (OR 6.75 [95% CI 2.41, 18.94]; p < 0.01). In CP cases, high AFP and high inhibin levels were associated with preterm birth and low birthweight.
Interpretation
Abnormal second‐trimester biomarker levels suggest abnormal placentation plays a role in the causal pathway of some CP cases.
Key points
What is already known about this topic?
Abnormal second‐trimester levels of biomarkers in maternal serum are associated with later cerebral palsy (CP).
Early pregnancy factors have potential importance in causal pathways to CP.
What does this study add?
Causal pathways involving placental dysfunction and genetic syndromes may be implicated.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - blood</subject><subject>Birth weight</subject><subject>Case-Control Studies</subject><subject>Cerebral palsy</subject><subject>Cerebral Palsy - diagnosis</subject><subject>Cerebral Palsy - epidemiology</subject><subject>Cerebral Palsy - genetics</subject><subject>Confidence intervals</subject><subject>Control data (computers)</subject><subject>Female</subject><subject>Genetics & Heredity</subject><subject>Humans</subject><subject>Inhibin</subject><subject>Life Sciences & Biomedicine</subject><subject>Mothers - statistics & numerical data</subject><subject>Obstetrics & Gynecology</subject><subject>Paralysis</subject><subject>Pituitary (anterior)</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second - blood</subject><subject>Pregnancy Trimester, Second - genetics</subject><subject>Premature birth</subject><subject>Prenatal Diagnosis - methods</subject><subject>Prenatal Diagnosis - standards</subject><subject>Prenatal Diagnosis - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>Science & Technology</subject><subject>Subgroups</subject><subject>Victoria - epidemiology</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkFtLxDAQhYMoul7wH0jBBwVZnSRNkzzKegVBQX0uaTvFatvUpEX235u66yKC4MvMMHxnOHMI2adwSgHYWVecJkDpGplQ0HIKjPF1MgEaZq4E3SLb3r8GUDEtN8kWj5kERfmE3D5ibtsi6l3VoO_RRY0JtTV15NENTZRVtjHuDZ2PzMi9YOQq_xbZMsrRYeYC2Znaz3fJRhk67i37Dnm-unya3Uzv7q9vZ-d305xLRUPFgpZSSCjR6IJiprUUGMskSYKrkiopSp5wNu4LoagGplmsw3dBqDnfIceLu52z70PwnDaVz7GuTYt28CkTgmkVwxd6-At9tcP420glIKRSTATqaEHlznrvsEy7EIZx85RCOqabdkU6phvIg-W9IWuwWHHfcQZALYAPzGzp8wrbHFcYACRSgBRxmIDOqt70lW1ndmj7ID35v_QHXdU4_8tw-nDx5fsTyYCgFA</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Peris, Monique</creator><creator>Reid, Susan M.</creator><creator>Dobie, Stephen</creator><creator>Bonacquisto, Leo</creator><creator>Shepherd, Daisy A.</creator><creator>Amor, David J.</creator><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7191-8511</orcidid><orcidid>https://orcid.org/0000-0001-8540-0473</orcidid></search><sort><creationdate>202108</creationdate><title>Second trimester maternal serum biomarkers and the risk of cerebral palsy</title><author>Peris, Monique ; Reid, Susan M. ; Dobie, Stephen ; Bonacquisto, Leo ; Shepherd, Daisy A. ; Amor, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3781-c3ed1f7570fea9d1eb9975e47666427f1875f3632b997d5819029249011ed1933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biomarkers</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - blood</topic><topic>Birth weight</topic><topic>Case-Control Studies</topic><topic>Cerebral palsy</topic><topic>Cerebral Palsy - diagnosis</topic><topic>Cerebral Palsy - epidemiology</topic><topic>Cerebral Palsy - genetics</topic><topic>Confidence intervals</topic><topic>Control data (computers)</topic><topic>Female</topic><topic>Genetics & Heredity</topic><topic>Humans</topic><topic>Inhibin</topic><topic>Life Sciences & Biomedicine</topic><topic>Mothers - statistics & numerical data</topic><topic>Obstetrics & Gynecology</topic><topic>Paralysis</topic><topic>Pituitary (anterior)</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second - blood</topic><topic>Pregnancy Trimester, Second - genetics</topic><topic>Premature birth</topic><topic>Prenatal Diagnosis - methods</topic><topic>Prenatal Diagnosis - standards</topic><topic>Prenatal Diagnosis - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>Science & Technology</topic><topic>Subgroups</topic><topic>Victoria - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peris, Monique</creatorcontrib><creatorcontrib>Reid, Susan M.</creatorcontrib><creatorcontrib>Dobie, Stephen</creatorcontrib><creatorcontrib>Bonacquisto, Leo</creatorcontrib><creatorcontrib>Shepherd, Daisy A.</creatorcontrib><creatorcontrib>Amor, David J.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peris, Monique</au><au>Reid, Susan M.</au><au>Dobie, Stephen</au><au>Bonacquisto, Leo</au><au>Shepherd, Daisy A.</au><au>Amor, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Second trimester maternal serum biomarkers and the risk of cerebral palsy</atitle><jtitle>Prenatal diagnosis</jtitle><stitle>PRENATAL DIAG</stitle><addtitle>Prenat Diagn</addtitle><date>2021-08</date><risdate>2021</risdate><volume>41</volume><issue>9</issue><spage>1101</spage><epage>1110</epage><pages>1101-1110</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><abstract>Aims
To investigate whether second trimester maternal serum screening (2TMSS) biomarkers are associated with cerebral palsy (CP) and identify CP characteristics associated with abnormal biomarker levels.
Method
In this retrospective case–control data linkage study, we linked mothers of 129 singleton CP cases from a population register to their 2TMSS records and selected 10 singleton pregnancy controls per case (n = 1290). We compared mean and abnormal levels of alpha‐fetoprotein (AFP), beta subunit of human chorionic gonadotrophin (β‐hCG), unconjugated estriol (uE3), and inhibin between cases and controls and within CP subgroups.
Results
Compared to control pregnancies, CP pregnancies had higher mean levels of AFP (1.10 vs. 1.01 multiple of the population median [MoM], p = 0.01) and inhibin (1.10 vs. 0.98 MoM, p ≤ 0.01). CP pregnancies were 2.5 times more likely to be associated with high levels of AFP (OR 2.52 [95% confidence interval [CI] 1.30, 4.65]; p < 0.01) and 2.6 times for inhibin (OR 2.63 [95% CI 1.37, 4.77]; p < 0.01), and 6.8 times when AFP and inhibin were both elevated (OR 6.75 [95% CI 2.41, 18.94]; p < 0.01). In CP cases, high AFP and high inhibin levels were associated with preterm birth and low birthweight.
Interpretation
Abnormal second‐trimester biomarker levels suggest abnormal placentation plays a role in the causal pathway of some CP cases.
Key points
What is already known about this topic?
Abnormal second‐trimester levels of biomarkers in maternal serum are associated with later cerebral palsy (CP).
Early pregnancy factors have potential importance in causal pathways to CP.
What does this study add?
Causal pathways involving placental dysfunction and genetic syndromes may be implicated.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>34270813</pmid><doi>10.1002/pd.6011</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7191-8511</orcidid><orcidid>https://orcid.org/0000-0001-8540-0473</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Analysis of Variance Biomarkers Biomarkers - analysis Biomarkers - blood Birth weight Case-Control Studies Cerebral palsy Cerebral Palsy - diagnosis Cerebral Palsy - epidemiology Cerebral Palsy - genetics Confidence intervals Control data (computers) Female Genetics & Heredity Humans Inhibin Life Sciences & Biomedicine Mothers - statistics & numerical data Obstetrics & Gynecology Paralysis Pituitary (anterior) Pregnancy Pregnancy Trimester, Second - blood Pregnancy Trimester, Second - genetics Premature birth Prenatal Diagnosis - methods Prenatal Diagnosis - standards Prenatal Diagnosis - statistics & numerical data Retrospective Studies Science & Technology Subgroups Victoria - epidemiology |
| title | Second trimester maternal serum biomarkers and the risk of cerebral palsy |
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