Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease

Electron transport chain (ETC) dysfunction or hypoxia causes toxic NADH accumulation. How cells regenerate NAD+ under such conditions remains elusive. Here, integrating bioinformatic analysis and experimental validation, we identify glycerol-3-phosphate (Gro3P) biosynthesis as an endogenous NAD+-reg...

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Veröffentlicht in:	Cell metabolism 2021-10, Vol.33 (10), p.1974-1987.e9
Hauptverfasser:	Liu, Shanshan, Fu, Song, Wang, Guodong, Cao, Yu, Li, Lanlan, Li, Xuemei, Yang, Jun, Li, Ning, Shan, Yabing, Cao, Yang, Ma, Yan, Dong, Mengqiu, Liu, Qinghua, Jiang, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans - metabolism Electron Transport Complex I - metabolism ETC dysfunction and hypoxia Glycerol - metabolism glycerol-3-phosphate biosynthesis Humans Mice mitochondrial complex I disease Mitochondrial Diseases NAD - metabolism NAD+ regeneration Oxidation-Reduction Phosphates - metabolism
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