High Neutrophil/Lymphocyte Ratios in Symptomatic Pediatric COVID-19 Patients
To investigate the symptoms and laboratory results of children hospitalised with the diagnosis of COVID-19, aiming to reveal the characteristics of symptomatic cases. A descriptive cross-sectional study. Department of Pediatrics, Kastamonu Training and Research Hospital, Kastamonu, Turkey from March...
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| Veröffentlicht in: | Journal of the College of Physicians and Surgeons--Pakistan 2021-07, Vol.31 (7), p.S93-S98 |
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| container_title | Journal of the College of Physicians and Surgeons--Pakistan |
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| creator | Yildiz, Eren Cigri, Emrah Dincer, Zubeyde Narsat, Mehmet Ali Calisir, Busra |
| description | To investigate the symptoms and laboratory results of children hospitalised with the diagnosis of COVID-19, aiming to reveal the characteristics of symptomatic cases.
A descriptive cross-sectional study.
Department of Pediatrics, Kastamonu Training and Research Hospital, Kastamonu, Turkey from March to December 2020.
Seventy-nine children, hospitalised with the diagnosis of COVID-19, were included in the study and were divided into two groups as symptomatic and asymptomatic. The demographic data, laboratory results and clinics of the patients of the two groups were compared.
The mean age of participants was 10.43 ± 5.91 (0-17) years, and 57% (n=45) of them were girls. Five patients in the symptomatic group had comorbidities (2 allergic asthma, cerebral palsy, type-1 diabetes mellitus and anorexia nervosa). The most common symptom was fever (36.7%, n=29). It was noteworthy that everyone with an NLR >3.13 (high-NLR) was symptomatic. Significantly more patients in the high-NLR group were symptomatic compared with the low-NLR group (p=0.005). On the other hand, symptomatic children had significantly higher levels of C-reactive protein (2.8 (IQR: 1.2-10.0) mg/L vs. 1.4 (IQR: 0.4-2.0) mg/L, p=0.011); and procalcitonin (0.05 (IQR: 0.02-0.10) ng/mL vs. 0.01 (IQR: 0.00-0.03) ng/mL, p |
| doi_str_mv | 10.29271/jcpsp.2021.Supp2.S93 |
| format | Article |
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A descriptive cross-sectional study.
Department of Pediatrics, Kastamonu Training and Research Hospital, Kastamonu, Turkey from March to December 2020.
Seventy-nine children, hospitalised with the diagnosis of COVID-19, were included in the study and were divided into two groups as symptomatic and asymptomatic. The demographic data, laboratory results and clinics of the patients of the two groups were compared.
The mean age of participants was 10.43 ± 5.91 (0-17) years, and 57% (n=45) of them were girls. Five patients in the symptomatic group had comorbidities (2 allergic asthma, cerebral palsy, type-1 diabetes mellitus and anorexia nervosa). The most common symptom was fever (36.7%, n=29). It was noteworthy that everyone with an NLR >3.13 (high-NLR) was symptomatic. Significantly more patients in the high-NLR group were symptomatic compared with the low-NLR group (p=0.005). On the other hand, symptomatic children had significantly higher levels of C-reactive protein (2.8 (IQR: 1.2-10.0) mg/L vs. 1.4 (IQR: 0.4-2.0) mg/L, p=0.011); and procalcitonin (0.05 (IQR: 0.02-0.10) ng/mL vs. 0.01 (IQR: 0.00-0.03) ng/mL, p<0.001) than those without symptoms. One of the children with cerebral palsy died from pneumonia during the study.
C-reactive protein, procalcitonin and NLR levels were found to be significantly higher in symptomatic children. NLR can be suggested as a potential marker associated with disease severity in COVID-19 patients, which needs to be supported by other studies. Key Words: COVID-19, Children, Neutrophil / lymphocyte ratio, C-reactive protein, Procalcitonin.</description><identifier>ISSN: 1022-386X</identifier><identifier>EISSN: 1681-7168</identifier><identifier>DOI: 10.29271/jcpsp.2021.Supp2.S93</identifier><identifier>PMID: 34271803</identifier><language>eng</language><publisher>Pakistan</publisher><subject>Adolescent ; Child ; Child, Preschool ; COVID-19 - blood ; Cross-Sectional Studies ; Female ; Humans ; Lymphocytes - metabolism ; Male ; Neutrophils - metabolism ; Pediatrics ; Retrospective Studies ; SARS-CoV-2 ; Turkey - epidemiology</subject><ispartof>Journal of the College of Physicians and Surgeons--Pakistan, 2021-07, Vol.31 (7), p.S93-S98</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2713-97ca59adc21fdf338fca86d2cf36c68361e86ab0ce8806ba6d915c39e2d635703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34271803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yildiz, Eren</creatorcontrib><creatorcontrib>Cigri, Emrah</creatorcontrib><creatorcontrib>Dincer, Zubeyde</creatorcontrib><creatorcontrib>Narsat, Mehmet Ali</creatorcontrib><creatorcontrib>Calisir, Busra</creatorcontrib><title>High Neutrophil/Lymphocyte Ratios in Symptomatic Pediatric COVID-19 Patients</title><title>Journal of the College of Physicians and Surgeons--Pakistan</title><addtitle>J Coll Physicians Surg Pak</addtitle><description>To investigate the symptoms and laboratory results of children hospitalised with the diagnosis of COVID-19, aiming to reveal the characteristics of symptomatic cases.
A descriptive cross-sectional study.
Department of Pediatrics, Kastamonu Training and Research Hospital, Kastamonu, Turkey from March to December 2020.
Seventy-nine children, hospitalised with the diagnosis of COVID-19, were included in the study and were divided into two groups as symptomatic and asymptomatic. The demographic data, laboratory results and clinics of the patients of the two groups were compared.
The mean age of participants was 10.43 ± 5.91 (0-17) years, and 57% (n=45) of them were girls. Five patients in the symptomatic group had comorbidities (2 allergic asthma, cerebral palsy, type-1 diabetes mellitus and anorexia nervosa). The most common symptom was fever (36.7%, n=29). It was noteworthy that everyone with an NLR >3.13 (high-NLR) was symptomatic. Significantly more patients in the high-NLR group were symptomatic compared with the low-NLR group (p=0.005). On the other hand, symptomatic children had significantly higher levels of C-reactive protein (2.8 (IQR: 1.2-10.0) mg/L vs. 1.4 (IQR: 0.4-2.0) mg/L, p=0.011); and procalcitonin (0.05 (IQR: 0.02-0.10) ng/mL vs. 0.01 (IQR: 0.00-0.03) ng/mL, p<0.001) than those without symptoms. One of the children with cerebral palsy died from pneumonia during the study.
C-reactive protein, procalcitonin and NLR levels were found to be significantly higher in symptomatic children. NLR can be suggested as a potential marker associated with disease severity in COVID-19 patients, which needs to be supported by other studies. Key Words: COVID-19, Children, Neutrophil / lymphocyte ratio, C-reactive protein, Procalcitonin.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>COVID-19 - blood</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Neutrophils - metabolism</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>SARS-CoV-2</subject><subject>Turkey - epidemiology</subject><issn>1022-386X</issn><issn>1681-7168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EoqXwCaAs2ST1Azv2EpVHK0W0ooDYWa7t0FRJY-xk0b_HLYXNzJ3HnZEOANcIZljgHI032gWXYYhRtuydw9lSkBMwRIyjNI_xNGqIcUo4-xyAixA2EBKKOD8HA3IXL3BIhqCYVl_r5MX2nW_duqrHxa5x61bvOpu8qq5qQ1Jtk2Vsdm0Ta50srKlU56OazD9mDykSySIO7LYLl-CsVHWwV8c8Au9Pj2-TaVrMn2eT-yLV8S1JRa4VFcpojEpTEsJLrTgzWJeEacYJQ5YztYLacg7ZSjEjENVEWGwYoTkkI3D7e9f59ru3oZNNFbSta7W1bR8kphSLXCC2X6W_q9q3IXhbSuerRvmdRFAeQMoDSLkHKQ8gZQQZfTfHF_2qsebf9UeO_ADGdHGa</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Yildiz, Eren</creator><creator>Cigri, Emrah</creator><creator>Dincer, Zubeyde</creator><creator>Narsat, Mehmet Ali</creator><creator>Calisir, Busra</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202107</creationdate><title>High Neutrophil/Lymphocyte Ratios in Symptomatic Pediatric COVID-19 Patients</title><author>Yildiz, Eren ; Cigri, Emrah ; Dincer, Zubeyde ; Narsat, Mehmet Ali ; Calisir, Busra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2713-97ca59adc21fdf338fca86d2cf36c68361e86ab0ce8806ba6d915c39e2d635703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>COVID-19 - blood</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphocytes - metabolism</topic><topic>Male</topic><topic>Neutrophils - metabolism</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><topic>SARS-CoV-2</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yildiz, Eren</creatorcontrib><creatorcontrib>Cigri, Emrah</creatorcontrib><creatorcontrib>Dincer, Zubeyde</creatorcontrib><creatorcontrib>Narsat, Mehmet Ali</creatorcontrib><creatorcontrib>Calisir, Busra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yildiz, Eren</au><au>Cigri, Emrah</au><au>Dincer, Zubeyde</au><au>Narsat, Mehmet Ali</au><au>Calisir, Busra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Neutrophil/Lymphocyte Ratios in Symptomatic Pediatric COVID-19 Patients</atitle><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle><addtitle>J Coll Physicians Surg Pak</addtitle><date>2021-07</date><risdate>2021</risdate><volume>31</volume><issue>7</issue><spage>S93</spage><epage>S98</epage><pages>S93-S98</pages><issn>1022-386X</issn><eissn>1681-7168</eissn><abstract>To investigate the symptoms and laboratory results of children hospitalised with the diagnosis of COVID-19, aiming to reveal the characteristics of symptomatic cases.
A descriptive cross-sectional study.
Department of Pediatrics, Kastamonu Training and Research Hospital, Kastamonu, Turkey from March to December 2020.
Seventy-nine children, hospitalised with the diagnosis of COVID-19, were included in the study and were divided into two groups as symptomatic and asymptomatic. The demographic data, laboratory results and clinics of the patients of the two groups were compared.
The mean age of participants was 10.43 ± 5.91 (0-17) years, and 57% (n=45) of them were girls. Five patients in the symptomatic group had comorbidities (2 allergic asthma, cerebral palsy, type-1 diabetes mellitus and anorexia nervosa). The most common symptom was fever (36.7%, n=29). It was noteworthy that everyone with an NLR >3.13 (high-NLR) was symptomatic. Significantly more patients in the high-NLR group were symptomatic compared with the low-NLR group (p=0.005). On the other hand, symptomatic children had significantly higher levels of C-reactive protein (2.8 (IQR: 1.2-10.0) mg/L vs. 1.4 (IQR: 0.4-2.0) mg/L, p=0.011); and procalcitonin (0.05 (IQR: 0.02-0.10) ng/mL vs. 0.01 (IQR: 0.00-0.03) ng/mL, p<0.001) than those without symptoms. One of the children with cerebral palsy died from pneumonia during the study.
C-reactive protein, procalcitonin and NLR levels were found to be significantly higher in symptomatic children. NLR can be suggested as a potential marker associated with disease severity in COVID-19 patients, which needs to be supported by other studies. Key Words: COVID-19, Children, Neutrophil / lymphocyte ratio, C-reactive protein, Procalcitonin.</abstract><cop>Pakistan</cop><pmid>34271803</pmid><doi>10.29271/jcpsp.2021.Supp2.S93</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Child Child, Preschool COVID-19 - blood Cross-Sectional Studies Female Humans Lymphocytes - metabolism Male Neutrophils - metabolism Pediatrics Retrospective Studies SARS-CoV-2 Turkey - epidemiology |
| title | High Neutrophil/Lymphocyte Ratios in Symptomatic Pediatric COVID-19 Patients |
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