Propofol alleviates neuropathic pain in chronic constriction injury rat models via the microRNA‐140‐3p/Jagged‐1 peptide/Notch signaling pathway

Chronic constriction injury (CCI) of the sciatic nerve was used to establish neuropathic pain (NP) models in rats. CCI rats were then treated with propofol (Pro) and their paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) were measured. In addition, the expression...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2021-10, Vol.75 (10), p.e22219-n/a
Hauptverfasser:	Cheng, Fang, Qin, Wei, Yang, Ai‐xing, Yan, Feng‐feng, Chen, Yu, Ma, Jian‐Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animal models Animals Constriction HES1 Hyperalgesia Inflammation inflammatory cytokine Jagged-1 Protein - genetics Jagged-1 Protein - metabolism Jagged-1 Protein - pharmacology Latency MicroRNAs - genetics MicroRNAs - metabolism miRNA miR‐140‐3p Neuralgia Neuralgia - drug therapy Neuralgia - metabolism neuropathic pain Notch1 Pain Pain perception Propofol Propofol - pharmacology Propofol - therapeutic use Rats Rats, Sprague-Dawley Sciatic nerve Signal Transduction targeted inhibition Tumor necrosis factor Tumor necrosis factor-TNF
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