Acetate differentially regulates IgA reactivity to commensal bacteria

The balance between bacterial colonization and its containment in the intestine is indispensable for the symbiotic relationship between humans and their bacteria. One component to maintain homeostasis at the mucosal surfaces is immunoglobulin A (IgA), the most abundant immunoglobulin in mammals 1 ,...

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Veröffentlicht in:	Nature (London) 2021-07, Vol.595 (7868), p.560-564
Hauptverfasser:	Takeuchi, Tadashi, Miyauchi, Eiji, Kanaya, Takashi, Kato, Tamotsu, Nakanishi, Yumiko, Watanabe, Takashi, Kitami, Toshimori, Taida, Takashi, Sasaki, Takaharu, Negishi, Hiroki, Shimamoto, Shu, Matsuyama, Akinobu, Kimura, Ikuo, Williams, Ifor R., Ohara, Osamu, Ohno, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 631/250/347 631/326/2565/2134 64/60 Acetates Acetates - pharmacology Acetic acid Animals Bacteria Bacteria - immunology CD4 antigen CD4-Positive T-Lymphocytes - immunology Cellulose acetate Colon Colon - immunology Colonization Containment Diet Digestive system E coli Enterobacterales Fatty Acids, Volatile - metabolism Gastrointestinal Microbiome - immunology Gastrointestinal tract Homeostasis Homeostasis - immunology Humanities and Social Sciences Humans Immune system Immunoglobulin A Immunoglobulin A - immunology Immunoglobulins Intestine Localization Lymphocytes Lymphocytes T Male Metabolites Mice Mice, Inbred C57BL Mice, Knockout Microorganisms Mucosa multidisciplinary Physiological aspects Science Science (multidisciplinary) Symbiosis
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