Sesquiterpenes and sesquiterpenoids harbor modulatory allosteric potential and affect inhibitory GABAA receptor function in vitro

Naturally occurring compounds such as sesquiterpenes and sesquiterpenoids (SQTs) have been shown to modulate GABAA receptors (GABAARs). In this study, the modulatory potential of 11 SQTs at GABAARs was analyzed to characterize their potential neurotropic activity. Transfected HEK293 cells and primar...

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Veröffentlicht in:	Journal of neurochemistry 2021-10, Vol.159 (1), p.101-115
Hauptverfasser:	Janzen, Dieter, Slavik, Benedikt, Zehe, Markus, Sotriffer, Christoph, Loos, Helene M., Buettner, Andrea, Villmann, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	allosteric modulation Allosteric properties Binding sites Caryophyllene GABAA receptor Hippocampus Humulene Isoforms Modulation Neurons patch clamp recording Receptors Sesquiterpenes Sesquiterpenoids γ-Aminobutyric acid A receptors
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