Memory-related process in physiological status and alzheimer’s disease
Rejecting central dogma around static status of adult mammalian brain, CNS has the nascent neurons generated in subgranular zone of dentate gyrus in hippocampus which develop to novel glutamatergic granule cells, with the innate feature of transmuting to memory disks. Structural plasticity proceeds...
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| Veröffentlicht in: | Molecular biology reports 2020-06, Vol.47 (6), p.4651-4657 |
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| creator | Fotuhi, Seyedeh Nahid Khalaj-Kondori, Mohammad Feizi, Mohammad Ali Hoseinpour Talebi, Mahnaz |
| description | Rejecting central dogma around static status of adult mammalian brain, CNS has the nascent neurons generated in subgranular zone of dentate gyrus in hippocampus which develop to novel glutamatergic granule cells, with the innate feature of transmuting to memory disks. Structural plasticity proceeds with synaptic plasticity to process all the developing stages required to successful maturation and functional integration, whereby the memory context is ready to leave the hippocampus toward cortex network through consolidation process, for being installed and run the memory disk forever. However, in Alzheimer’s disease, brain deal with subtle deadly progressive loss of synapsis, neuronal dysfunction and ultimately network failure, resulting in memory decay and cognitive decline—concluding that AD destroys memory formation related-pathways. |
| doi_str_mv | 10.1007/s11033-020-05438-y |
| format | Article |
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Structural plasticity proceeds with synaptic plasticity to process all the developing stages required to successful maturation and functional integration, whereby the memory context is ready to leave the hippocampus toward cortex network through consolidation process, for being installed and run the memory disk forever. 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physiology</subject><subject>Morphology</subject><subject>Nerve Net - physiology</subject><subject>Neurodegenerative diseases</subject><subject>Neurogenesis</subject><subject>Neuronal Plasticity - physiology</subject><subject>neurons</subject><subject>Neurons - physiology</subject><subject>neuroplasticity</subject><subject>physiological state</subject><subject>plasticity</subject><subject>Review</subject><subject>Synaptic plasticity</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkbtOHTEQhq2ICA4nvEAKtBINjcP4htdlhCBEIqKht-zdWVi0l4Nnt1gqXoPXy5PE5JBESgHVFP7mn_F8jH0W8EUA2BMSApTiIIGD0arkywe2EsYqrp0td9gKFAiuSyP22D7RPQBoYc0u21NSWiehXLHLH9iPaeEJuzBhXWzSWCFR0Q7F5m6hduzG27YKXUFTmGYqwlAXoXu8w7bH9PPpmYq6JQyEn9jHJnSEB691zW4uzm_OLvnV9bfvZ1-veKWhnLhrQrTBmTrGCCo2p-As1jFYqW3eKYQQy1NprG6iFhWgaGRtHBgVNegK1Zodb2Pzog8z0uT7lirsujDgOJOXxghntVDufVSVTuZD5iOu2dF_6P04pyH_Iwdaa7XWIDIlt1SVRqKEjd-ktg9p8QL8ixG_NeKzEf_biF9y0-Fr9Bx7rP-2_FGQAbUFKD8Nt5j-zX4j9heED5dp</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Fotuhi, Seyedeh Nahid</creator><creator>Khalaj-Kondori, Mohammad</creator><creator>Feizi, Mohammad Ali Hoseinpour</creator><creator>Talebi, Mahnaz</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-7613-3913</orcidid><orcidid>https://orcid.org/0000-0003-4287-7233</orcidid></search><sort><creationdate>20200601</creationdate><title>Memory-related process in physiological status and alzheimer’s disease</title><author>Fotuhi, Seyedeh Nahid ; Khalaj-Kondori, Mohammad ; Feizi, Mohammad Ali Hoseinpour ; Talebi, Mahnaz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-9fab7a95dbbb03bf6097edba7247279aaab862574fb41c0e1f2d59053b404ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>adults</topic><topic>Alzheimer Disease - 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| subjects | adults Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Animal Anatomy Animal Biochemistry Animals Biomedical and Life Sciences Brain - physiology cognition Cognitive ability cortex Dentate gyrus Disease Models, Animal Glutamatergic transmission Granule cells Hippocampus Hippocampus - physiology Histology Humans Life Sciences mammals Memory Memory - physiology Morphology Nerve Net - physiology Neurodegenerative diseases Neurogenesis Neuronal Plasticity - physiology neurons Neurons - physiology neuroplasticity physiological state plasticity Review Synaptic plasticity |
| title | Memory-related process in physiological status and alzheimer’s disease |
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