An injectable bioactive magnesium phosphate cement incorporating carboxymethyl chitosan for bone regeneration

Magnesium phosphate cement (MPC) can be injected to form an in situ scaffold to repair bone defects. Here we synthesized novel injectable bioactive cements (CMPCs) by incorporating different ratios of carboxymethyl chitosan (CMC, 0–10%) into MPC. The physiochemical properties, compositions, and micr...

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Veröffentlicht in:	International journal of biological macromolecules 2020-10, Vol.160, p.101-111
Hauptverfasser:	Yu, Ling, Xia, Kezhou, Gong, Changtian, Chen, Jingteng, Li, Wei, Zhao, Yanan, Guo, Weichun, Dai, Honglian
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells adhesion adsorption Animals Biocompatible Materials - chemistry Bone Cements - chemistry Bone Cements - pharmacology Bone regeneration Bone Regeneration - drug effects Carboxymethyl chitosan Cell Adhesion - drug effects Cell Differentiation - drug effects Cell Line Cell Proliferation - drug effects cement chitosan Chitosan - analogs & derivatives Chitosan - chemistry Chitosan - pharmacology compression strength Compressive Strength - drug effects fibronectins Fibronectins - metabolism Focal Adhesion Kinase 1 - metabolism Hydrogen-Ion Concentration integrins magnesium Magnesium Compounds - chemistry Magnesium Compounds - pharmacology Magnesium phosphate cement MAP Kinase Signaling System - drug effects Materials Testing - methods Mice osteoblasts Osteoblasts - drug effects Osteoblasts - metabolism phosphates Phosphates - chemistry Phosphates - pharmacology phosphorylation Phosphorylation - drug effects Physicochemical properties Signal Transduction - drug effects Temperature
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