Molecular pathways related to the control of proliferation and cell death in 786-O cells treated with plumbagin

Plumbagin (PLB) is a phytochemical being used for centuries in traditional medicines. Recently, its capacity to inhibit the development of human tumors has been observed, through the induction of apoptosis, cell cycle arrest, and inhibition of angiogenesis and metastasis. Here we evaluated the mecha...

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Veröffentlicht in:	Molecular biology reports 2019-12, Vol.46 (6), p.6071-6078
Hauptverfasser:	Mancilla, Igor Alves, Coatti, Giuliana Castello, Biazi, Bruna Isabela, Zanetti, Thalita Alves, Baranoski, Adrivanio, Marques, Lilian Areal, Corveloni, Amanda Cristina, Lepri, Sandra Regina, Mantovani, Mario Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - metabolism Angiogenesis Animal Anatomy Animal Biochemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Autophagy - drug effects Biomedical and Life Sciences Cell cycle cell cycle checkpoints Cell Cycle Checkpoints - drug effects Cell death Cell Death - drug effects Cell Line, Tumor - drug effects cell lines Cell membranes Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cytotoxicity Gene expression Genotoxicity GTP-binding protein Histology Humans Kidney Neoplasms - metabolism kidneys Life Sciences MDM2 protein mechanism of action Metastases metastasis Morphology mutagens Naphthoquinones - metabolism Naphthoquinones - pharmacology Original Article p38 Mitogen-Activated Protein Kinases - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation phytochemicals Phytochemicals - metabolism Phytochemicals - pharmacology Plumbagin protein content Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects TOR protein TOR Serine-Threonine Kinases - metabolism Tumors
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