CytomegaloVirusDb: Multi-omics knowledge database for cytomegaloviruses

Cytomegalovirus infection is a significant health concern and need further exploration in immunologic response mechanisms during primary and reactivated CMV infection. In this work, we evaluated the whole genomes and proteomes of different CMV species and developed an integrated open-access platform, CytomegaloVirusDb, a multi-Omics knowledge database for Cytomegaloviruses. The resource is categorized into the main sections “Genomics,” “Proteomics,” “Immune response,” and “Therapeutics,“. The database is annotated with the list of all CMV species included in the study, and available information is freely accessible at http://www.cmvdb.dqweilab-sjtu.com/index.php. Various parameters used in the analysis for each section were primarily based on the whole genome or proteome of each specie. The platform provided datasets are open to access for researchers to obtain CMV species-specific information. This will help further to explore the dynamics of CMV-specific immune response and therapeutics. This platform is a useful resource to aid in advancing research against Cytomegaloviruses. [Display omitted] •Cytomegalovirus infection is a significant health concern.•In this work, we developed CytomegaloVirusDb database for Cytomegaloviruses.•CTL, HTL, B-cell epitopes and RNA therapeutics are deployed online at http://www.cmvdb.dqweilab-sjtu.com/index.php.•Various parameters used in the analysis are primarily based on the whole genome or proteome of each specie.•The platform would help to accelerate vaccines and RNA therapeutics development against the CMV species.