The impact of clonal diversity and mosaicism on haematopoietic function in Fanconi anaemia

Summary Recent advances have facilitated studies of the clonal architecture of the aging haematopoietic system, and provided clues to the mechanisms underlying the origins of hematopoietic malignancy. Much less is known about the clonal composition of haematopoiesis and its impact in bone marrow fai...

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Veröffentlicht in:	British journal of haematology 2022-01, Vol.196 (2), p.274-287
Hauptverfasser:	Hughes, Andrew D., Kurre, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Anemia Animals Biomarkers Bone composition Bone marrow bone marrow failure Cell Differentiation - genetics Cell Tracking Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism clonal evolution Clonal Evolution - genetics clonality Combined Modality Therapy Cytogenetic Analysis Disease Management Disease Susceptibility DNA Damage Fanconi anaemia Fanconi Anemia - diagnosis Fanconi Anemia - etiology Fanconi Anemia - metabolism Fanconi Anemia - therapy Gene Expression Regulation Gene therapy Genetic Therapy Genetic Variation Hematology Hematopoiesis - genetics Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Malignancy Molecular Imaging Mosaicism Signal Transduction Stem cells
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