Synthesis and Characterization of New V1A Antagonist Compounds: The Separation of Four Atropisomeric Stereoisomers

A new class of selective vasopressin receptor 1A (V1A) antagonists was identified, where “methyl-scan” was performed around the benzene ring of the 5-hydroxy-triazolobenzazepine core. This led to the synthesis of two 10-methyl derivatives, each possessing a chiral axis and a stereogenic center. The...

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Veröffentlicht in:	Journal of medicinal chemistry 2021-07, Vol.64 (14), p.10445-10468
Hauptverfasser:	Szeleczky, Zsolt, Szakács, Zoltán, Bozó, Éva, Baska, Ferenc, Vukics, Krisztina, Lévai, Sándor, Temesvári, Krisztina, Vass, Elemér, Béni, Zoltán, Krámos, Balázs, Magdó, Ildikó, Szántay, Csaba, Kóti, János, Domány-Kovács, Katalin, Greiner, István, Bata, Imre
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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