Mechanometabolism: Mitochondria promote resilience under pressure

Mechanometabolism: Mitochondria promote resilience under pressure

Mechanical forces regulate metabolism in healthy and cancerous tissue. A new study reveals that extracellular matrix stiffness modulates mitochondrial shape and function. The mechanical reprogramming of mitochondria confers resistance to oxidative stress and promotes survival. Mechanical forces regu...

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Veröffentlicht in:Current biology 2021-07, Vol.31 (13), p.R859-R861
Hauptverfasser: MacVicar, Thomas, Langer, Thomas
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Sprache:eng
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Mitochondria - metabolism
Oxidative Stress - physiology
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container_title Current biology
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creator MacVicar, Thomas
Langer, Thomas
description Mechanical forces regulate metabolism in healthy and cancerous tissue. A new study reveals that extracellular matrix stiffness modulates mitochondrial shape and function. The mechanical reprogramming of mitochondria confers resistance to oxidative stress and promotes survival. Mechanical forces regulate metabolism in healthy and cancerous tissue. A new study reveals that extracellular matrix stiffness modulates mitochondrial shape and function. The mechanical reprogramming of mitochondria confers resistance to oxidative stress and promotes survival.
doi_str_mv 10.1016/j.cub.2021.05.065
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source MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; EZB-FREE-00999 freely available EZB journals
subjects Mitochondria - metabolism
Oxidative Stress - physiology
title Mechanometabolism: Mitochondria promote resilience under pressure
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