Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges

The CNS is ensheathed by the meninges and cerebrospinal fluid, and recent findings suggest that these CNS-associated border tissues have complex immunological functions. Unlike myeloid lineage cells, lymphocytes in border compartments have yet to be thoroughly characterized. Based on single-cell tra...

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Veröffentlicht in:	Nature neuroscience 2021-09, Vol.24 (9), p.1225-1234
Hauptverfasser:	Schafflick, David, Wolbert, Jolien, Heming, Michael, Thomas, Christian, Hartlehnert, Maike, Börsch, Anna-Lena, Ricci, Alessio, Martín-Salamanca, Sandra, Li, Xiaolin, Lu, I-Na, Pawlak, Mathias, Minnerup, Jens, Strecker, Jan-Kolja, Seidenbecher, Thomas, Meuth, Sven G., Hidalgo, Andres, Liesz, Arthur, Wiendl, Heinz, Meyer zu Horste, Gerd
Format:	Artikel
Sprache:	eng
Schlagworte:	14 38/32 38/39 38/91 631/61/514/1949 692/698/1688/1366 692/699/249/2510 692/699/375/1666 Animal Genetics and Genomics Animals B cells B-Lymphocytes - immunology Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Bone marrow Cerebrospinal fluid Choroid plexus Development and progression Dura mater Health aspects Homeostasis Immunology Inflammation Leukocytes Lymphocytes Lymphocytes B Meninges Meninges - immunology Mice Neurobiology Neurosciences Parenchyma Physiological aspects Precursor Cells, B-Lymphoid - immunology Progenitor cells Rats Single-Cell Analysis Skull Stem cells Tissues
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