Synthesis, characterization, and cellular investigations of porphyrin- and chlorin-indomethacin conjugates for photodynamic therapy of cancer

Indomethacin is a potent non-steroidal anti-inflammatory drug (NSAID) with a strong selective inhibitor activity towards cyclooxygenase-2 (COX-2), an enzyme that is highly overexpressed in various tumour cells, being involved in tumourigenesis. Concomitantly, porphyrins have gained much attention as...

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Veröffentlicht in:	Organic & biomolecular chemistry 2021-07, Vol.19 (29), p.651-6512
Hauptverfasser:	Almeida, José, Zhang, Guanyu, Wang, Maodie, Queirós, Carla, Cerqueira, Ana F. R, Tomé, Augusto C, Barone, Giampaolo, Vicente, M. Graça H, Hey-Hawkins, Evamarie, Silva, Ana M. G, Rangel, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Atomic energy levels Cancer Cell Line, Tumor Cell Survival - drug effects Conjugates Cyclooxygenase-2 Cytotoxicity Density Functional Theory Drug Screening Assays, Antitumor High resolution Humans Indomethacin Indomethacin - chemistry Indomethacin - pharmacology Inflammation Isomers Localization Mass spectrometry Mass spectroscopy Mathematical analysis Molecular Structure NMR Nonsteroidal anti-inflammatory drugs Nuclear magnetic resonance Oxygen Photochemotherapy Photodynamic therapy Photosensitizing Agents - chemical synthesis Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Porphyrins Porphyrins - chemical synthesis Porphyrins - chemistry Porphyrins - pharmacology Scientific imaging Singlet oxygen Singlet Oxygen - metabolism Spectroscopy Toxicity Triplet state Tumorigenesis Tumors
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