A Prospective Study of Intraarterial Infusion Chemotherapy in Advanced Wild-Type BRAF Melanoma Patients

•Treatment strategies for advanced cutaneous melanoma patients, ineligible for novel target and immunotherapies, remain a challenge.•In a BRAF wild-type cutaneous melanoma subgroup, not eligible for immunotherapy, presenting with metastases localized to inferior limbs and pelvis, melphalan locoregio...

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Veröffentlicht in:	The Journal of surgical research 2021-12, Vol.268, p.737-747
Hauptverfasser:	Guadagni, Stefano, Zoras, Odysseas, Fiorentini, Giammaria, Masedu, Francesco, Lasithiotakis, Konstantinos, Sarti, Donatella, Farina, Antonietta Rosella, Mackay, Andrew Reay, Clementi, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	BRAF wild-type Chemotherapy, Cancer, Regional Perfusion Extremities - pathology Humans Hyperthermic isolated limb perfusion Hypoxic pelvic and limb perfusion Infusions, Intra-Arterial Isolated limb infusion Locoregional metastases Melanoma - drug therapy Melanoma - genetics Melanoma - pathology Melphalan Melphalan - therapeutic use Novel immunotherapies Prospective Studies Proto-Oncogene Proteins B-raf - genetics Recurrent melanoma Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - pathology
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