24-Hour Multichannel Intraluminal Impedance–pH in Proton Pump Inhibitor Nonresponders vs Responders in Patients With Laryngopharyngeal Reflux
Objective This study aimed to evaluate the characteristics of reflux in proton pump inhibitor (PPI) nonresponders vs responders in patients with laryngopharyngeal reflux (LPR) by using 24-hour multichannel intraluminal impedance–pH (MII-pH) monitoring. Study Design Prospective cohort study. Setting...
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 2022-05, Vol.166 (5), p.910-916 |
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| container_title | Otolaryngology-head and neck surgery |
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| creator | Kim, Su Il Jeong, Su Jin Kwon, Oh Eun Park, Jung Min Lee, Young Chan Eun, Young-Gyu Ko, Seong-Gyu |
| description | Objective
This study aimed to evaluate the characteristics of reflux in proton pump inhibitor (PPI) nonresponders vs responders in patients with laryngopharyngeal reflux (LPR) by using 24-hour multichannel intraluminal impedance–pH (MII-pH) monitoring.
Study Design
Prospective cohort study.
Setting
A tertiary care otolaryngology clinic.
Methods
Patients with typical LPR symptoms showing >1 proximal reflux episode were considered to have LPR and investigated prospectively. Patients were prescribed high-dose PPI twice daily and followed up for at least 2 months. Patients with LPR showing a ≥50% decrease in the follow-up reflux symptom index score during treatment periods as compared with pretreatment were defined as responders; others were defined as nonresponders. Various parameters in 24-hour MII-pH monitoring between nonresponders and responders with LPR were compared with Student’s t test and receiver operating characteristic curve.
Results
Eighty patients were diagnosed with LPR and categorized as nonresponders (n = 19) and responders (n = 61). Proximal all reflux time and proximal longest reflux time in various MII parameters were higher in responders than in nonresponders (P = .0040 and .0216, respectively). Proximal all reflux time >0.000517% was a better cutoff value to predict responders with LPR as compared with the proximal longest reflux time >0.61 minutes (sensitivity + specificity: 1.317 vs 1.291).
Conclusion
Proximal all reflux time in various 24-hour MII-pH monitoring parameters can be helpful to predict the response to PPI therapy in patients with LPR. These findings will help establish a personalized therapeutic scheme for patients with LPR. |
| doi_str_mv | 10.1177/01945998211026843 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2551210530</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_01945998211026843</sage_id><sourcerecordid>2551210530</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3902-1f31262da596dca0e93a6a958e672d27030e087091e99bd4b6051e40bca045653</originalsourceid><addsrcrecordid>eNqFkc1O3DAUha2qqEyhD9BN5WU3gWsntuNliwqDNPwIUXUZOckdxiixUzspsOMNuugb9knwMFAWldrV0ZW_c3x1DyHvGewxptQ-MF0IrUvOGHBZFvkrMmOgVSZLpl6T2fo9WwPb5G2M1wAgpVJvyHZecJGDKmbkJy-yuZ8CPZm60TYr4xx29NiNwXRTb51JQz9ga1yDv-9_DXNqHT0PfvRJpn5I6MrWdvSBnnoXMA7etRgi_RHpxcu0NpnRohsj_WbHFV2YcOeu_LB6VEzfXOCym253ydbSdBHfPekO-Xr45fJgni3Ojo4PPi2yJtfAM7bMGZe8NULLtjGAOjfSaFGiVLzlCnJAKBVohlrXbVFLEAwLqBNbCCnyHfJxkzsE_33COFa9jQ12nXHop1hxIRhnkK6UULZBm-BjDLishmD7tHfFoFr3UP3VQ_J8eIqf6h7bP47nwydAb4Ab2-Hd_xOrs_np50PQkvHk3dt4o7nC6jq1l2qK_9jmAepeons</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2551210530</pqid></control><display><type>article</type><title>24-Hour Multichannel Intraluminal Impedance–pH in Proton Pump Inhibitor Nonresponders vs Responders in Patients With Laryngopharyngeal Reflux</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><source>Wiley Online Library All Journals</source><creator>Kim, Su Il ; Jeong, Su Jin ; Kwon, Oh Eun ; Park, Jung Min ; Lee, Young Chan ; Eun, Young-Gyu ; Ko, Seong-Gyu</creator><creatorcontrib>Kim, Su Il ; Jeong, Su Jin ; Kwon, Oh Eun ; Park, Jung Min ; Lee, Young Chan ; Eun, Young-Gyu ; Ko, Seong-Gyu</creatorcontrib><description>Objective
This study aimed to evaluate the characteristics of reflux in proton pump inhibitor (PPI) nonresponders vs responders in patients with laryngopharyngeal reflux (LPR) by using 24-hour multichannel intraluminal impedance–pH (MII-pH) monitoring.
Study Design
Prospective cohort study.
Setting
A tertiary care otolaryngology clinic.
Methods
Patients with typical LPR symptoms showing >1 proximal reflux episode were considered to have LPR and investigated prospectively. Patients were prescribed high-dose PPI twice daily and followed up for at least 2 months. Patients with LPR showing a ≥50% decrease in the follow-up reflux symptom index score during treatment periods as compared with pretreatment were defined as responders; others were defined as nonresponders. Various parameters in 24-hour MII-pH monitoring between nonresponders and responders with LPR were compared with Student’s t test and receiver operating characteristic curve.
Results
Eighty patients were diagnosed with LPR and categorized as nonresponders (n = 19) and responders (n = 61). Proximal all reflux time and proximal longest reflux time in various MII parameters were higher in responders than in nonresponders (P = .0040 and .0216, respectively). Proximal all reflux time >0.000517% was a better cutoff value to predict responders with LPR as compared with the proximal longest reflux time >0.61 minutes (sensitivity + specificity: 1.317 vs 1.291).
Conclusion
Proximal all reflux time in various 24-hour MII-pH monitoring parameters can be helpful to predict the response to PPI therapy in patients with LPR. These findings will help establish a personalized therapeutic scheme for patients with LPR.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1177/01945998211026843</identifier><identifier>PMID: 34253074</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Electric Impedance ; Esophageal pH Monitoring ; Humans ; Hydrogen-Ion Concentration ; laryngopharyngeal reflux ; Laryngopharyngeal Reflux - diagnosis ; Laryngopharyngeal Reflux - drug therapy ; multichannel intraluminal impedance–pH (MII‐pH) ; nonresponder ; Prospective Studies ; proton pump inhibitor ; Proton Pump Inhibitors - therapeutic use</subject><ispartof>Otolaryngology-head and neck surgery, 2022-05, Vol.166 (5), p.910-916</ispartof><rights>American Academy of Otolaryngology–Head and Neck Surgery Foundation 2021</rights><rights>2022 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3902-1f31262da596dca0e93a6a958e672d27030e087091e99bd4b6051e40bca045653</citedby><cites>FETCH-LOGICAL-c3902-1f31262da596dca0e93a6a958e672d27030e087091e99bd4b6051e40bca045653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/01945998211026843$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/01945998211026843$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,1416,21818,27923,27924,43620,43621,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34253074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Su Il</creatorcontrib><creatorcontrib>Jeong, Su Jin</creatorcontrib><creatorcontrib>Kwon, Oh Eun</creatorcontrib><creatorcontrib>Park, Jung Min</creatorcontrib><creatorcontrib>Lee, Young Chan</creatorcontrib><creatorcontrib>Eun, Young-Gyu</creatorcontrib><creatorcontrib>Ko, Seong-Gyu</creatorcontrib><title>24-Hour Multichannel Intraluminal Impedance–pH in Proton Pump Inhibitor Nonresponders vs Responders in Patients With Laryngopharyngeal Reflux</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>Objective
This study aimed to evaluate the characteristics of reflux in proton pump inhibitor (PPI) nonresponders vs responders in patients with laryngopharyngeal reflux (LPR) by using 24-hour multichannel intraluminal impedance–pH (MII-pH) monitoring.
Study Design
Prospective cohort study.
Setting
A tertiary care otolaryngology clinic.
Methods
Patients with typical LPR symptoms showing >1 proximal reflux episode were considered to have LPR and investigated prospectively. Patients were prescribed high-dose PPI twice daily and followed up for at least 2 months. Patients with LPR showing a ≥50% decrease in the follow-up reflux symptom index score during treatment periods as compared with pretreatment were defined as responders; others were defined as nonresponders. Various parameters in 24-hour MII-pH monitoring between nonresponders and responders with LPR were compared with Student’s t test and receiver operating characteristic curve.
Results
Eighty patients were diagnosed with LPR and categorized as nonresponders (n = 19) and responders (n = 61). Proximal all reflux time and proximal longest reflux time in various MII parameters were higher in responders than in nonresponders (P = .0040 and .0216, respectively). Proximal all reflux time >0.000517% was a better cutoff value to predict responders with LPR as compared with the proximal longest reflux time >0.61 minutes (sensitivity + specificity: 1.317 vs 1.291).
Conclusion
Proximal all reflux time in various 24-hour MII-pH monitoring parameters can be helpful to predict the response to PPI therapy in patients with LPR. These findings will help establish a personalized therapeutic scheme for patients with LPR.</description><subject>Electric Impedance</subject><subject>Esophageal pH Monitoring</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>laryngopharyngeal reflux</subject><subject>Laryngopharyngeal Reflux - diagnosis</subject><subject>Laryngopharyngeal Reflux - drug therapy</subject><subject>multichannel intraluminal impedance–pH (MII‐pH)</subject><subject>nonresponder</subject><subject>Prospective Studies</subject><subject>proton pump inhibitor</subject><subject>Proton Pump Inhibitors - therapeutic use</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1O3DAUha2qqEyhD9BN5WU3gWsntuNliwqDNPwIUXUZOckdxiixUzspsOMNuugb9knwMFAWldrV0ZW_c3x1DyHvGewxptQ-MF0IrUvOGHBZFvkrMmOgVSZLpl6T2fo9WwPb5G2M1wAgpVJvyHZecJGDKmbkJy-yuZ8CPZm60TYr4xx29NiNwXRTb51JQz9ga1yDv-9_DXNqHT0PfvRJpn5I6MrWdvSBnnoXMA7etRgi_RHpxcu0NpnRohsj_WbHFV2YcOeu_LB6VEzfXOCym253ydbSdBHfPekO-Xr45fJgni3Ojo4PPi2yJtfAM7bMGZe8NULLtjGAOjfSaFGiVLzlCnJAKBVohlrXbVFLEAwLqBNbCCnyHfJxkzsE_33COFa9jQ12nXHop1hxIRhnkK6UULZBm-BjDLishmD7tHfFoFr3UP3VQ_J8eIqf6h7bP47nwydAb4Ab2-Hd_xOrs_np50PQkvHk3dt4o7nC6jq1l2qK_9jmAepeons</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Kim, Su Il</creator><creator>Jeong, Su Jin</creator><creator>Kwon, Oh Eun</creator><creator>Park, Jung Min</creator><creator>Lee, Young Chan</creator><creator>Eun, Young-Gyu</creator><creator>Ko, Seong-Gyu</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202205</creationdate><title>24-Hour Multichannel Intraluminal Impedance–pH in Proton Pump Inhibitor Nonresponders vs Responders in Patients With Laryngopharyngeal Reflux</title><author>Kim, Su Il ; Jeong, Su Jin ; Kwon, Oh Eun ; Park, Jung Min ; Lee, Young Chan ; Eun, Young-Gyu ; Ko, Seong-Gyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3902-1f31262da596dca0e93a6a958e672d27030e087091e99bd4b6051e40bca045653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Electric Impedance</topic><topic>Esophageal pH Monitoring</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>laryngopharyngeal reflux</topic><topic>Laryngopharyngeal Reflux - diagnosis</topic><topic>Laryngopharyngeal Reflux - drug therapy</topic><topic>multichannel intraluminal impedance–pH (MII‐pH)</topic><topic>nonresponder</topic><topic>Prospective Studies</topic><topic>proton pump inhibitor</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Su Il</creatorcontrib><creatorcontrib>Jeong, Su Jin</creatorcontrib><creatorcontrib>Kwon, Oh Eun</creatorcontrib><creatorcontrib>Park, Jung Min</creatorcontrib><creatorcontrib>Lee, Young Chan</creatorcontrib><creatorcontrib>Eun, Young-Gyu</creatorcontrib><creatorcontrib>Ko, Seong-Gyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Su Il</au><au>Jeong, Su Jin</au><au>Kwon, Oh Eun</au><au>Park, Jung Min</au><au>Lee, Young Chan</au><au>Eun, Young-Gyu</au><au>Ko, Seong-Gyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>24-Hour Multichannel Intraluminal Impedance–pH in Proton Pump Inhibitor Nonresponders vs Responders in Patients With Laryngopharyngeal Reflux</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2022-05</date><risdate>2022</risdate><volume>166</volume><issue>5</issue><spage>910</spage><epage>916</epage><pages>910-916</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Objective
This study aimed to evaluate the characteristics of reflux in proton pump inhibitor (PPI) nonresponders vs responders in patients with laryngopharyngeal reflux (LPR) by using 24-hour multichannel intraluminal impedance–pH (MII-pH) monitoring.
Study Design
Prospective cohort study.
Setting
A tertiary care otolaryngology clinic.
Methods
Patients with typical LPR symptoms showing >1 proximal reflux episode were considered to have LPR and investigated prospectively. Patients were prescribed high-dose PPI twice daily and followed up for at least 2 months. Patients with LPR showing a ≥50% decrease in the follow-up reflux symptom index score during treatment periods as compared with pretreatment were defined as responders; others were defined as nonresponders. Various parameters in 24-hour MII-pH monitoring between nonresponders and responders with LPR were compared with Student’s t test and receiver operating characteristic curve.
Results
Eighty patients were diagnosed with LPR and categorized as nonresponders (n = 19) and responders (n = 61). Proximal all reflux time and proximal longest reflux time in various MII parameters were higher in responders than in nonresponders (P = .0040 and .0216, respectively). Proximal all reflux time >0.000517% was a better cutoff value to predict responders with LPR as compared with the proximal longest reflux time >0.61 minutes (sensitivity + specificity: 1.317 vs 1.291).
Conclusion
Proximal all reflux time in various 24-hour MII-pH monitoring parameters can be helpful to predict the response to PPI therapy in patients with LPR. These findings will help establish a personalized therapeutic scheme for patients with LPR.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>34253074</pmid><doi>10.1177/01945998211026843</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0194-5998 |
| ispartof | Otolaryngology-head and neck surgery, 2022-05, Vol.166 (5), p.910-916 |
| issn | 0194-5998 1097-6817 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2551210530 |
| source | MEDLINE; SAGE Complete A-Z List; Wiley Online Library All Journals |
| subjects | Electric Impedance Esophageal pH Monitoring Humans Hydrogen-Ion Concentration laryngopharyngeal reflux Laryngopharyngeal Reflux - diagnosis Laryngopharyngeal Reflux - drug therapy multichannel intraluminal impedance–pH (MII‐pH) nonresponder Prospective Studies proton pump inhibitor Proton Pump Inhibitors - therapeutic use |
| title | 24-Hour Multichannel Intraluminal Impedance–pH in Proton Pump Inhibitor Nonresponders vs Responders in Patients With Laryngopharyngeal Reflux |
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