Novel Phenyl‐Based Bis‐quaternary Ammonium Compounds as Broad‐Spectrum Biocides

Herein we report the synthesis and microbiological evaluation of novel phenyl based bis‐quaternary ammonium compounds (bis‐QACs). Using a simple 2‐step synthetic route from dibromo‐ and dihydroxybenzenes, we obtained a structurally diverse broad panel of bis‐QACs with topologically distinct bridging...

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Veröffentlicht in:	ChemMedChem 2021-10, Vol.16 (19), p.2954-2959
Hauptverfasser:	Frolov, Nikita A., Fedoseeva, Ksenia A., Hansford, Karl A., Vereshchagin, Anatoly N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii - drug effects Ammonium Ammonium compounds Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibacterial activity antifungal activity Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antiseptics Bacteria Biocides Candida albicans - drug effects Cryptococcus neoformans - drug effects Cytotoxicity Dihydroxybenzenes Disinfectants - chemical synthesis Disinfectants - chemistry Disinfectants - pharmacology Dose-Response Relationship, Drug E coli Escherichia coli - drug effects Fungi Klebsiella Klebsiella pneumoniae - drug effects Methicillin Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Minimum inhibitory concentration Molecular Structure Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pyridinium pyridinium salts Quaternary ammonium compounds Quaternary Ammonium Compounds - chemical synthesis Quaternary Ammonium Compounds - chemistry Quaternary Ammonium Compounds - pharmacology Quaternary ammonium salts Sanitizers Structure-Activity Relationship Toxicity
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