The protein disulphide isomerase inhibitor CxxCpep modulates oxidative burst and mitochondrial function in platelets

We have previously described CxxCpep, a peptide with anti-platelet properties that inhibits peri/epicellular protein disulphide isomerase (pecPDI) by forming a mixed disulfide bond with Cys400 within the pecPDI active site. Here we sought to determine if pecPDI targeted by CxxCpep is relevant to red...

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Veröffentlicht in:	Free radical biology & medicine 2021-08, Vol.172, p.668-674
Hauptverfasser:	Gaspar, Renato S., Mansilla, Santiago, Vieira, Victor A., da Silva, Ludmila B., Gibbins, Jonathan M., Castro, Laura, Trostchansky, Andrés, Paes, Antonio Marcus de A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry & Molecular Biology Collagen Endocrinology & Metabolism Life Sciences & Biomedicine Platelet inhibitor Platelets Protein disulphide isomerase Redox biology Science & Technology
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