Guaianolide Sesquiterpenes With Significant Antiproliferative Activities From the Leaves of Artemisia argyi
Four new guaiane-type sesquiterpenes, argyin H–K (1–4), and two known analogues (5 and 6) were isolated from the leaves of Artemisia argyi Lévl et Vant. The new compounds were characterized by the basic analysis of the spectroscopic data obtained ( 1 H NMR, 13 C NMR, HMBC, and NOESY experiments), an...
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| Veröffentlicht in: | Frontiers in chemistry 2021-06, Vol.9, p.698700-698700 |
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| creator | Ming, Wenzhuo Zhang, Yi Sun, Yiwei Bi, Guangming Su, Jing Shao, Zhutao Meng, Dali |
| description | Four new guaiane-type sesquiterpenes, argyin H–K (1–4), and two known analogues (5 and 6) were isolated from the leaves of
Artemisia argyi
Lévl et Vant. The new compounds were characterized by the basic analysis of the spectroscopic data obtained (
1
H NMR,
13
C NMR, HMBC, and NOESY experiments), and their absolute configurations were determined by empirical approaches, combined with the exciton chirality method and electronic circular dichroism calculations. To further understand the antitumor effects of
A. argyi
, the antiproliferative activities of these compounds against A549, MCF-7, and HepG2 cell lines were tested
in vitro
using CCK-8 assays. The results showed that these compounds had significant antiproliferative effects on MCF-7, with IC
50
values of 15.13–18.63 μM, which were superior to that of oxaliplatin (i.e., IC
50
22.20 μM). |
| doi_str_mv | 10.3389/fchem.2021.698700 |
| format | Article |
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Artemisia argyi
Lévl et Vant. The new compounds were characterized by the basic analysis of the spectroscopic data obtained (
1
H NMR,
13
C NMR, HMBC, and NOESY experiments), and their absolute configurations were determined by empirical approaches, combined with the exciton chirality method and electronic circular dichroism calculations. To further understand the antitumor effects of
A. argyi
, the antiproliferative activities of these compounds against A549, MCF-7, and HepG2 cell lines were tested
in vitro
using CCK-8 assays. The results showed that these compounds had significant antiproliferative effects on MCF-7, with IC
50
values of 15.13–18.63 μM, which were superior to that of oxaliplatin (i.e., IC
50
22.20 μM).</description><identifier>ISSN: 2296-2646</identifier><identifier>EISSN: 2296-2646</identifier><identifier>DOI: 10.3389/fchem.2021.698700</identifier><identifier>PMID: 34249868</identifier><language>eng</language><publisher>Frontiers Media S.A</publisher><subject>antiproliferative ; antitumor ; Artemisia argyi ; Chemistry ; configuration determination ; guaiane-type sesquiterpenoids</subject><ispartof>Frontiers in chemistry, 2021-06, Vol.9, p.698700-698700</ispartof><rights>Copyright © 2021 Ming, Zhang, Sun, Bi, Su, Shao and Meng. 2021 Ming, Zhang, Sun, Bi, Su, Shao and Meng</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-7694a57aa7c7a37e95516348de930f07a78b94a5d850879a7ed21540bc9bf4103</citedby><cites>FETCH-LOGICAL-c372t-7694a57aa7c7a37e95516348de930f07a78b94a5d850879a7ed21540bc9bf4103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263895/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263895/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Ming, Wenzhuo</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Sun, Yiwei</creatorcontrib><creatorcontrib>Bi, Guangming</creatorcontrib><creatorcontrib>Su, Jing</creatorcontrib><creatorcontrib>Shao, Zhutao</creatorcontrib><creatorcontrib>Meng, Dali</creatorcontrib><title>Guaianolide Sesquiterpenes With Significant Antiproliferative Activities From the Leaves of Artemisia argyi</title><title>Frontiers in chemistry</title><description>Four new guaiane-type sesquiterpenes, argyin H–K (1–4), and two known analogues (5 and 6) were isolated from the leaves of
Artemisia argyi
Lévl et Vant. The new compounds were characterized by the basic analysis of the spectroscopic data obtained (
1
H NMR,
13
C NMR, HMBC, and NOESY experiments), and their absolute configurations were determined by empirical approaches, combined with the exciton chirality method and electronic circular dichroism calculations. To further understand the antitumor effects of
A. argyi
, the antiproliferative activities of these compounds against A549, MCF-7, and HepG2 cell lines were tested
in vitro
using CCK-8 assays. The results showed that these compounds had significant antiproliferative effects on MCF-7, with IC
50
values of 15.13–18.63 μM, which were superior to that of oxaliplatin (i.e., IC
50
22.20 μM).</description><subject>antiproliferative</subject><subject>antitumor</subject><subject>Artemisia argyi</subject><subject>Chemistry</subject><subject>configuration determination</subject><subject>guaiane-type sesquiterpenoids</subject><issn>2296-2646</issn><issn>2296-2646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkU1rGzEQhpfS0oQ0P6C3PfZiV1-rj0vBhCYNGHpIS49iVjuyle6uHEk25N9HjkNITq9m9PLMMG_TfKVkybk2373b4rRkhNGlNFoR8qE5Z8zIBZNCfnzzPmsuc74nhFBGuWDkc3NWRRgt9Xnz_2YPAeY4hgHbO8wP-1Aw7XDG3P4LZdvehc0cfHAwl3Y1l7BL1esxQQkHbFeuSiihuq9TnNqyxXaNcKh19O0qFZxCDtBC2jyGL80nD2PGyxe9aP5e__xz9Wux_n1ze7VaLxxXrCyUNAI6BaCcAq7QdB2VXOgBDSeeKFC6PzoG3RGtDCgcGO0E6Z3pvaCEXzS3J-4Q4d7uUpggPdoIwT43YtpYSCW4Ea0wknonGeFEC619LzqpBzmIWtSBtLJ-nFi7fT_h4HAuCcZ30Pc_c9jaTTxYzWRNqauAby-AFB_2mIutF3E4jjBj3GfLuo5ILrU-7k1PVpdizgn96xhK7DFz-5y5PWZuT5nzJ2pGn_s</recordid><startdate>20210624</startdate><enddate>20210624</enddate><creator>Ming, Wenzhuo</creator><creator>Zhang, Yi</creator><creator>Sun, Yiwei</creator><creator>Bi, Guangming</creator><creator>Su, Jing</creator><creator>Shao, Zhutao</creator><creator>Meng, Dali</creator><general>Frontiers Media S.A</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210624</creationdate><title>Guaianolide Sesquiterpenes With Significant Antiproliferative Activities From the Leaves of Artemisia argyi</title><author>Ming, Wenzhuo ; Zhang, Yi ; Sun, Yiwei ; Bi, Guangming ; Su, Jing ; Shao, Zhutao ; Meng, Dali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-7694a57aa7c7a37e95516348de930f07a78b94a5d850879a7ed21540bc9bf4103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>antiproliferative</topic><topic>antitumor</topic><topic>Artemisia argyi</topic><topic>Chemistry</topic><topic>configuration determination</topic><topic>guaiane-type sesquiterpenoids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ming, Wenzhuo</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Sun, Yiwei</creatorcontrib><creatorcontrib>Bi, Guangming</creatorcontrib><creatorcontrib>Su, Jing</creatorcontrib><creatorcontrib>Shao, Zhutao</creatorcontrib><creatorcontrib>Meng, Dali</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ming, Wenzhuo</au><au>Zhang, Yi</au><au>Sun, Yiwei</au><au>Bi, Guangming</au><au>Su, Jing</au><au>Shao, Zhutao</au><au>Meng, Dali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Guaianolide Sesquiterpenes With Significant Antiproliferative Activities From the Leaves of Artemisia argyi</atitle><jtitle>Frontiers in chemistry</jtitle><date>2021-06-24</date><risdate>2021</risdate><volume>9</volume><spage>698700</spage><epage>698700</epage><pages>698700-698700</pages><issn>2296-2646</issn><eissn>2296-2646</eissn><abstract>Four new guaiane-type sesquiterpenes, argyin H–K (1–4), and two known analogues (5 and 6) were isolated from the leaves of
Artemisia argyi
Lévl et Vant. The new compounds were characterized by the basic analysis of the spectroscopic data obtained (
1
H NMR,
13
C NMR, HMBC, and NOESY experiments), and their absolute configurations were determined by empirical approaches, combined with the exciton chirality method and electronic circular dichroism calculations. To further understand the antitumor effects of
A. argyi
, the antiproliferative activities of these compounds against A549, MCF-7, and HepG2 cell lines were tested
in vitro
using CCK-8 assays. The results showed that these compounds had significant antiproliferative effects on MCF-7, with IC
50
values of 15.13–18.63 μM, which were superior to that of oxaliplatin (i.e., IC
50
22.20 μM).</abstract><pub>Frontiers Media S.A</pub><pmid>34249868</pmid><doi>10.3389/fchem.2021.698700</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | antiproliferative antitumor Artemisia argyi Chemistry configuration determination guaiane-type sesquiterpenoids |
| title | Guaianolide Sesquiterpenes With Significant Antiproliferative Activities From the Leaves of Artemisia argyi |
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