The Resilient Phenotype Induced by Prophylactic Ketamine Exposure During Adolescence Is Mediated by the Ventral Tegmental Area–Nucleus Accumbens Pathway

Major depressive disorder is prevalent in children and adolescents and is associated with a high degree of morbidity throughout life, with potentially devastating personal consequences and public health impact. The efficacy of ketamine (KET) as an antidepressant has been demonstrated in adolescent r...

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Veröffentlicht in:	Biological psychiatry (1969) 2021-10, Vol.90 (7), p.482-493
Hauptverfasser:	Parise, Eric M., Parise, Lyonna F., Sial, Omar K., Cardona-Acosta, Astrid M., Gyles, Trevonn M., Juarez, Barbara, Chaudhury, Dipesh, Han, Ming-Hu, Nestler, Eric J., Bolaños-Guzmán, Carlos A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Animals Depression Depressive Disorder, Major Ketamine Male Mesocorticolimbic Mice Mice, Inbred C57BL Nucleus Accumbens Phenotype Prophylactic Resilience Ventral Tegmental Area
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