Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin

Doxorubicin conjugated with nanodiamonds via hydrazone bond is a slow-release form of doxorubicin in the cytoplasm inducing endoplasmic reticulum stress but minimal DNA damage and thus does not activate MDR mechanisms associated with doxorubicin. [Display omitted] Doxorubicin (DOX) has been widely i...

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Veröffentlicht in:	International journal of pharmaceutics 2021-09, Vol.606, p.120872-120872, Article 120872
Hauptverfasser:	Yuan, Shen-Jun, Wang, Chao, Xu, Hua-Zhen, Liu, Yan, Zheng, Mei-Yan, Li, Ke, Sun, Shi-Kuan, Komatsu, Naoki, Zhao, Li, Chen, Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemoresistance DNA damage response Doxorubicin Endoplasmic reticulum stress Hydrazone bond Inflammation Nanodiamond
Online-Zugang:	Volltext
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