mTOR Inhibition Promotes Pneumonitis through Inducing Endothelial Contraction and Hyperpermeability

Compromised endothelial-cell (EC) barrier function is a hallmark of inflammatory diseases. mTOR inhibitors, widely applied as clinical therapies, cause pneumonitis through mechanisms that are not yet fully understood. This study aimed to elucidate the EC mechanisms underlying the pathogenesis of pne...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2021-12, Vol.65 (6), p.646-657
Hauptverfasser:	Chen, Xiaolin, Hu, Chengxiu, Fan, Xing, Wang, Yiying, Li, Qiannan, Su, You-Qiang, Zhang, Dai-Min, Yang, QianLu, Passerini, Anthony G, Sun, ChongXiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Birds of prey Contraction Electrical resistivity Human Umbilical Vein Endothelial Cells - enzymology Humans Inflammation Inflammatory diseases Kinases Lipopolysaccharides Lipopolysaccharides - toxicity MAP Kinase Signaling System - drug effects Mice Mice, Knockout MTOR Inhibitors - adverse effects MTOR Inhibitors - pharmacology Myosin Myosin Light Chains - metabolism Myosin-light-chain kinase Myosin-light-chain-phosphatase Permeability Phosphorylation Phosphorylation - drug effects Plasmids Pneumonia - chemically induced Pneumonia - enzymology Pneumonitis Protein kinase C Protein synthesis siRNA TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism
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