Protective Effect of Selenium-Enriched Green Tea on Carbon Tetrachloride-Induced Liver Fibrosis
The major pathogenic feature of liver fibrosis is that oxidative stress motivation of hepatic stellate cells (HSCs) alters the balance between the synthesis and degradation of extracellular matrix (ECM) and HSCs into proliferative myofibroblasts. Green tea and selenium (Se) can protect the liver fro...
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| Veröffentlicht in: | Biological trace element research 2022-05, Vol.200 (5), p.2233-2238 |
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| creator | Zhang, Lin Xu, Jia-Ying Wei, Yanyan Gao, Shi-Lin Wang, Lin Zheng, Jia-Yang Gu, Minghua Qin, Li-Qiang |
| description | The major pathogenic feature of liver fibrosis is that oxidative stress motivation of hepatic stellate cells (HSCs) alters the balance between the synthesis and degradation of extracellular matrix (ECM) and HSCs into proliferative myofibroblasts. Green tea and selenium (Se) can protect the liver from damage; however, the precise mechanism of green tea and the action of Se in green tea on hepatic fibrosis remain unclear. Several studies have demonstrated the profibrogenic role of 5-hydroxytryptamine (5-HT) and 5-hydroxytryptamine receptor (5-HTR) 2A/2B in the liver. The current study aimed to investigate the protective effects and possible mechanisms of selenium-enriched green tea on carbon tetrachloride (CCl
4
)-induced liver fibrosis in male C57BL/6 J mice. After a 4-week intervention with tea solution, histological analysis of the liver showed that green tea interventions alleviated hepatic fibrosis, which was supported by the changes in collagen type I, collagen type III, and α-smooth muscle actin in the liver. Tea interventions significantly inhibited the CCl
4
-provoked increase of duodenal 5-HT and tryptophan hydroxylase and hepatic 5-HT and 5-HTR2A/2B levels. All of them were lower in the selenium-enriched green tea group than in regular green tea group. Se-enriched green tea had a more pronounced improvement in liver ECM deposition and scar formation and peripheral 5-HT signals than regular green tea. Thus, green tea, especially those enriched with selenium, can improve liver fibrosis through intestinal 5-HT-hepatic 5-HTR signaling. |
| doi_str_mv | 10.1007/s12011-021-02823-x |
| format | Article |
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4
)-induced liver fibrosis in male C57BL/6 J mice. After a 4-week intervention with tea solution, histological analysis of the liver showed that green tea interventions alleviated hepatic fibrosis, which was supported by the changes in collagen type I, collagen type III, and α-smooth muscle actin in the liver. Tea interventions significantly inhibited the CCl
4
-provoked increase of duodenal 5-HT and tryptophan hydroxylase and hepatic 5-HT and 5-HTR2A/2B levels. All of them were lower in the selenium-enriched green tea group than in regular green tea group. Se-enriched green tea had a more pronounced improvement in liver ECM deposition and scar formation and peripheral 5-HT signals than regular green tea. Thus, green tea, especially those enriched with selenium, can improve liver fibrosis through intestinal 5-HT-hepatic 5-HTR signaling.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-021-02823-x</identifier><identifier>PMID: 34251588</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Actin ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Carbon ; Carbon tetrachloride ; Carbon Tetrachloride - toxicity ; Collagen ; Collagen (type I) ; Collagen (type III) ; Enrichment ; Extracellular ; Extracellular matrix ; Fibrosis ; Green tea ; Life Sciences ; Liver ; Liver - metabolism ; Liver Cirrhosis - chemically induced ; Liver Cirrhosis - metabolism ; Liver Cirrhosis - prevention & control ; Male ; Mice ; Mice, Inbred C57BL ; Motivation ; Muscles ; Nutrition ; Oncology ; Oxidative stress ; Pathogens ; Receptors ; Selenium ; Selenium - metabolism ; Serotonin - metabolism ; Smooth muscle ; Stellate cells ; Tea ; Tryptophan ; Tryptophan hydroxylase</subject><ispartof>Biological trace element research, 2022-05, Vol.200 (5), p.2233-2238</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-eab0fc377b2edd84aaeebae6d52fd384509bab070f3c6fbb1828099c7b2750783</citedby><cites>FETCH-LOGICAL-c375t-eab0fc377b2edd84aaeebae6d52fd384509bab070f3c6fbb1828099c7b2750783</cites><orcidid>0000-0002-5231-2562</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-021-02823-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-021-02823-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34251588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Xu, Jia-Ying</creatorcontrib><creatorcontrib>Wei, Yanyan</creatorcontrib><creatorcontrib>Gao, Shi-Lin</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Zheng, Jia-Yang</creatorcontrib><creatorcontrib>Gu, Minghua</creatorcontrib><creatorcontrib>Qin, Li-Qiang</creatorcontrib><title>Protective Effect of Selenium-Enriched Green Tea on Carbon Tetrachloride-Induced Liver Fibrosis</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>The major pathogenic feature of liver fibrosis is that oxidative stress motivation of hepatic stellate cells (HSCs) alters the balance between the synthesis and degradation of extracellular matrix (ECM) and HSCs into proliferative myofibroblasts. Green tea and selenium (Se) can protect the liver from damage; however, the precise mechanism of green tea and the action of Se in green tea on hepatic fibrosis remain unclear. Several studies have demonstrated the profibrogenic role of 5-hydroxytryptamine (5-HT) and 5-hydroxytryptamine receptor (5-HTR) 2A/2B in the liver. The current study aimed to investigate the protective effects and possible mechanisms of selenium-enriched green tea on carbon tetrachloride (CCl
4
)-induced liver fibrosis in male C57BL/6 J mice. After a 4-week intervention with tea solution, histological analysis of the liver showed that green tea interventions alleviated hepatic fibrosis, which was supported by the changes in collagen type I, collagen type III, and α-smooth muscle actin in the liver. Tea interventions significantly inhibited the CCl
4
-provoked increase of duodenal 5-HT and tryptophan hydroxylase and hepatic 5-HT and 5-HTR2A/2B levels. All of them were lower in the selenium-enriched green tea group than in regular green tea group. Se-enriched green tea had a more pronounced improvement in liver ECM deposition and scar formation and peripheral 5-HT signals than regular green tea. Thus, green tea, especially those enriched with selenium, can improve liver fibrosis through intestinal 5-HT-hepatic 5-HTR signaling.</description><subject>Actin</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Carbon</subject><subject>Carbon tetrachloride</subject><subject>Carbon Tetrachloride - toxicity</subject><subject>Collagen</subject><subject>Collagen (type I)</subject><subject>Collagen (type III)</subject><subject>Enrichment</subject><subject>Extracellular</subject><subject>Extracellular matrix</subject><subject>Fibrosis</subject><subject>Green tea</subject><subject>Life Sciences</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Liver Cirrhosis - chemically induced</subject><subject>Liver Cirrhosis - metabolism</subject><subject>Liver Cirrhosis - prevention & control</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Motivation</subject><subject>Muscles</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Oxidative stress</subject><subject>Pathogens</subject><subject>Receptors</subject><subject>Selenium</subject><subject>Selenium - 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Academic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Lin</au><au>Xu, Jia-Ying</au><au>Wei, Yanyan</au><au>Gao, Shi-Lin</au><au>Wang, Lin</au><au>Zheng, Jia-Yang</au><au>Gu, Minghua</au><au>Qin, Li-Qiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Effect of Selenium-Enriched Green Tea on Carbon Tetrachloride-Induced Liver Fibrosis</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>200</volume><issue>5</issue><spage>2233</spage><epage>2238</epage><pages>2233-2238</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>The major pathogenic feature of liver fibrosis is that oxidative stress motivation of hepatic stellate cells (HSCs) alters the balance between the synthesis and degradation of extracellular matrix (ECM) and HSCs into proliferative myofibroblasts. Green tea and selenium (Se) can protect the liver from damage; however, the precise mechanism of green tea and the action of Se in green tea on hepatic fibrosis remain unclear. Several studies have demonstrated the profibrogenic role of 5-hydroxytryptamine (5-HT) and 5-hydroxytryptamine receptor (5-HTR) 2A/2B in the liver. The current study aimed to investigate the protective effects and possible mechanisms of selenium-enriched green tea on carbon tetrachloride (CCl
4
)-induced liver fibrosis in male C57BL/6 J mice. After a 4-week intervention with tea solution, histological analysis of the liver showed that green tea interventions alleviated hepatic fibrosis, which was supported by the changes in collagen type I, collagen type III, and α-smooth muscle actin in the liver. Tea interventions significantly inhibited the CCl
4
-provoked increase of duodenal 5-HT and tryptophan hydroxylase and hepatic 5-HT and 5-HTR2A/2B levels. All of them were lower in the selenium-enriched green tea group than in regular green tea group. Se-enriched green tea had a more pronounced improvement in liver ECM deposition and scar formation and peripheral 5-HT signals than regular green tea. Thus, green tea, especially those enriched with selenium, can improve liver fibrosis through intestinal 5-HT-hepatic 5-HTR signaling.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34251588</pmid><doi>10.1007/s12011-021-02823-x</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5231-2562</orcidid></addata></record> |
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| subjects | Actin Animals Biochemistry Biomedical and Life Sciences Biotechnology Carbon Carbon tetrachloride Carbon Tetrachloride - toxicity Collagen Collagen (type I) Collagen (type III) Enrichment Extracellular Extracellular matrix Fibrosis Green tea Life Sciences Liver Liver - metabolism Liver Cirrhosis - chemically induced Liver Cirrhosis - metabolism Liver Cirrhosis - prevention & control Male Mice Mice, Inbred C57BL Motivation Muscles Nutrition Oncology Oxidative stress Pathogens Receptors Selenium Selenium - metabolism Serotonin - metabolism Smooth muscle Stellate cells Tea Tryptophan Tryptophan hydroxylase |
| title | Protective Effect of Selenium-Enriched Green Tea on Carbon Tetrachloride-Induced Liver Fibrosis |
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