Exploring the aging effect of the anticancer drugs doxorubicin and mitoxantrone on cardiac mitochondrial proteome using a murine model

•MTX and DOX in clinically relevant doses cause heart mitochondrial injury.•MTX causes more pronounced mitochondrial cardiac proteomic changes than DOX.•Neither MTX- nor DOX-induced proteomic changes resemble cardiac aging. Current cancer therapies are successfully increasing the lifespan of cancer...

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Veröffentlicht in:	Toxicology (Amsterdam) 2021-07, Vol.459, p.152852-152852, Article 152852
Hauptverfasser:	Brandão, Sofia Reis, Reis-Mendes, Ana, Domingues, Pedro, Duarte, José Alberto, Bastos, Maria Lourdes, Carvalho, Félix, Ferreira, Rita, Costa, Vera Marisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Cardiotoxicity Doxorubicin Mitochondria dynamics Mitoxantrone
Online-Zugang:	Volltext
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