QRISK3 relation to carotid plaque is higer than that of score in patients with systemic lupus erythematosus

Abstract Introduction SLE has been described as an independent risk factor for the development of cardiovascular (CV) disease. Recently, the QRESEARCH risk estimator version 3 (QRISK3) calculator has been launched for CV risk assessment in the general population. QRISK3 now includes the presence of...

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Veröffentlicht in:Rheumatology (Oxford, England) England), 2022-04, Vol.61 (4), p.1408-1416
Hauptverfasser: Quevedo-Abeledo, Juan Carlos, Caceres, Laura, Palazuelos, Camilo, Llorca, Javier, González-Gay, Miguel Á, Ferraz-Amaro, Iván
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container_end_page 1416
container_issue 4
container_start_page 1408
container_title Rheumatology (Oxford, England)
container_volume 61
creator Quevedo-Abeledo, Juan Carlos
Caceres, Laura
Palazuelos, Camilo
Llorca, Javier
González-Gay, Miguel Á
Ferraz-Amaro, Iván
description Abstract Introduction SLE has been described as an independent risk factor for the development of cardiovascular (CV) disease. Recently, the QRESEARCH risk estimator version 3 (QRISK3) calculator has been launched for CV risk assessment in the general population. QRISK3 now includes the presence of SLE as one of its variables for calculating CV risk. Our objective was to compare the predictive capacity between QRISK3 and the Systematic Coronary Risk Evaluation (SCORE) for the presence of subclinical carotid atherosclerosis in patients with SLE. Methods Two hundred and ninety-six patients with SLE were recruited. The presence of subclinical atherosclerosis was evaluated by carotid ultrasound to identify carotid plaque and the thickness of the carotid intima–media (cIMT). QRISK3 and SCORE were calculated. The relationship of QRISK3 and SCORE with each other and with the presence of subclinical carotid atherosclerosis (both carotid plaque and cIMT) was studied. Results There was no correlation between SCORE and QRISK3 in patients with SLE (Spearman’s rho = −0.008, P = 0.90). Although QRISK3 showed a statistically significant correlation with cIMT (Spearman’s rho = 0.420, P = 0.000), this relationship was not found between SCORE and cIMT (Spearman’s rho = −0.005, P = 0.93). The discrimination capacity of QRISK3 for the presence of carotid plaque was statistically significant and superior to that of SCORE (AUC 0.765 [95% CI: 0.711, 0.820] vs 0.561 [95% CI: 0.494, 0.629], P = 0.000). Conclusion QRISK3 discrimination for subclinical atherosclerosis is higher than that of SCORE. QRISK3, and not SCORE, should be used for the calculation of CV risk in patients with SLE.
doi_str_mv 10.1093/rheumatology/keab531
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Recently, the QRESEARCH risk estimator version 3 (QRISK3) calculator has been launched for CV risk assessment in the general population. QRISK3 now includes the presence of SLE as one of its variables for calculating CV risk. Our objective was to compare the predictive capacity between QRISK3 and the Systematic Coronary Risk Evaluation (SCORE) for the presence of subclinical carotid atherosclerosis in patients with SLE. Methods Two hundred and ninety-six patients with SLE were recruited. The presence of subclinical atherosclerosis was evaluated by carotid ultrasound to identify carotid plaque and the thickness of the carotid intima–media (cIMT). QRISK3 and SCORE were calculated. The relationship of QRISK3 and SCORE with each other and with the presence of subclinical carotid atherosclerosis (both carotid plaque and cIMT) was studied. Results There was no correlation between SCORE and QRISK3 in patients with SLE (Spearman’s rho = −0.008, P = 0.90). Although QRISK3 showed a statistically significant correlation with cIMT (Spearman’s rho = 0.420, P = 0.000), this relationship was not found between SCORE and cIMT (Spearman’s rho = −0.005, P = 0.93). The discrimination capacity of QRISK3 for the presence of carotid plaque was statistically significant and superior to that of SCORE (AUC 0.765 [95% CI: 0.711, 0.820] vs 0.561 [95% CI: 0.494, 0.629], P = 0.000). Conclusion QRISK3 discrimination for subclinical atherosclerosis is higher than that of SCORE. QRISK3, and not SCORE, should be used for the calculation of CV risk in patients with SLE.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/keab531</identifier><identifier>PMID: 34240117</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Atherosclerosis - etiology ; Cardiovascular Diseases - epidemiology ; Carotid Artery Diseases - complications ; Carotid Artery Diseases - etiology ; Carotid Intima-Media Thickness ; Humans ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - epidemiology ; Plaque, Atherosclerotic - complications ; Plaque, Atherosclerotic - etiology ; Risk Factors</subject><ispartof>Rheumatology (Oxford, England), 2022-04, Vol.61 (4), p.1408-1416</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c277t-39bedbc7c2b74213769def048212b1c173916831a430e63a68898f306919f8c73</citedby><cites>FETCH-LOGICAL-c277t-39bedbc7c2b74213769def048212b1c173916831a430e63a68898f306919f8c73</cites><orcidid>0000-0003-0197-5267</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34240117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quevedo-Abeledo, Juan Carlos</creatorcontrib><creatorcontrib>Caceres, Laura</creatorcontrib><creatorcontrib>Palazuelos, Camilo</creatorcontrib><creatorcontrib>Llorca, Javier</creatorcontrib><creatorcontrib>González-Gay, Miguel Á</creatorcontrib><creatorcontrib>Ferraz-Amaro, Iván</creatorcontrib><title>QRISK3 relation to carotid plaque is higer than that of score in patients with systemic lupus erythematosus</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>Abstract Introduction SLE has been described as an independent risk factor for the development of cardiovascular (CV) disease. Recently, the QRESEARCH risk estimator version 3 (QRISK3) calculator has been launched for CV risk assessment in the general population. QRISK3 now includes the presence of SLE as one of its variables for calculating CV risk. Our objective was to compare the predictive capacity between QRISK3 and the Systematic Coronary Risk Evaluation (SCORE) for the presence of subclinical carotid atherosclerosis in patients with SLE. Methods Two hundred and ninety-six patients with SLE were recruited. The presence of subclinical atherosclerosis was evaluated by carotid ultrasound to identify carotid plaque and the thickness of the carotid intima–media (cIMT). QRISK3 and SCORE were calculated. The relationship of QRISK3 and SCORE with each other and with the presence of subclinical carotid atherosclerosis (both carotid plaque and cIMT) was studied. Results There was no correlation between SCORE and QRISK3 in patients with SLE (Spearman’s rho = −0.008, P = 0.90). Although QRISK3 showed a statistically significant correlation with cIMT (Spearman’s rho = 0.420, P = 0.000), this relationship was not found between SCORE and cIMT (Spearman’s rho = −0.005, P = 0.93). The discrimination capacity of QRISK3 for the presence of carotid plaque was statistically significant and superior to that of SCORE (AUC 0.765 [95% CI: 0.711, 0.820] vs 0.561 [95% CI: 0.494, 0.629], P = 0.000). Conclusion QRISK3 discrimination for subclinical atherosclerosis is higher than that of SCORE. QRISK3, and not SCORE, should be used for the calculation of CV risk in patients with SLE.</description><subject>Atherosclerosis - etiology</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Carotid Artery Diseases - complications</subject><subject>Carotid Artery Diseases - etiology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - epidemiology</subject><subject>Plaque, Atherosclerotic - complications</subject><subject>Plaque, Atherosclerotic - etiology</subject><subject>Risk Factors</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAQhi0EoqXwBgj5yCXUW7YjqlgqKiG2c-Q4k8Y0iYPtCOXtSdVSceQyM9L8_ywfQpeU3FCS8rmtoG-kN7VZD_MNyDzk9AhNqYhYQDhnx4eaiQk6c-6TEBJSnpyiCRdMEErjKdq8vC7fnji2UEuvTYu9wUpa43WBu1p-9YC1w5Veg8W-ku02eGxK7JSxY6_F3eiD1jv8rX2F3eA8NFrhuu96h8EOvoLtma535-iklLWDi32eoY_7u_fFY7B6flgubleBYnHsA57mUOQqViyPBaM8jtICSiISRllOFY15SqOEUyk4gYjLKEnSpOQkSmlaJirmM3S9m9tZMz7gfNZop6CuZQumdxkLQ8JGV0hGqdhJlTXOWSizzupG2iGjJNtizv5izvaYR9vVfkOfN1AcTL9cR8F8JzB997-RP9MSjyQ</recordid><startdate>20220411</startdate><enddate>20220411</enddate><creator>Quevedo-Abeledo, Juan Carlos</creator><creator>Caceres, Laura</creator><creator>Palazuelos, Camilo</creator><creator>Llorca, Javier</creator><creator>González-Gay, Miguel Á</creator><creator>Ferraz-Amaro, Iván</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0197-5267</orcidid></search><sort><creationdate>20220411</creationdate><title>QRISK3 relation to carotid plaque is higer than that of score in patients with systemic lupus erythematosus</title><author>Quevedo-Abeledo, Juan Carlos ; Caceres, Laura ; Palazuelos, Camilo ; Llorca, Javier ; González-Gay, Miguel Á ; Ferraz-Amaro, Iván</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c277t-39bedbc7c2b74213769def048212b1c173916831a430e63a68898f306919f8c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Atherosclerosis - etiology</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Carotid Artery Diseases - complications</topic><topic>Carotid Artery Diseases - etiology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Humans</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - epidemiology</topic><topic>Plaque, Atherosclerotic - complications</topic><topic>Plaque, Atherosclerotic - etiology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quevedo-Abeledo, Juan Carlos</creatorcontrib><creatorcontrib>Caceres, Laura</creatorcontrib><creatorcontrib>Palazuelos, Camilo</creatorcontrib><creatorcontrib>Llorca, Javier</creatorcontrib><creatorcontrib>González-Gay, Miguel Á</creatorcontrib><creatorcontrib>Ferraz-Amaro, Iván</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quevedo-Abeledo, Juan Carlos</au><au>Caceres, Laura</au><au>Palazuelos, Camilo</au><au>Llorca, Javier</au><au>González-Gay, Miguel Á</au><au>Ferraz-Amaro, Iván</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>QRISK3 relation to carotid plaque is higer than that of score in patients with systemic lupus erythematosus</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2022-04-11</date><risdate>2022</risdate><volume>61</volume><issue>4</issue><spage>1408</spage><epage>1416</epage><pages>1408-1416</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><abstract>Abstract Introduction SLE has been described as an independent risk factor for the development of cardiovascular (CV) disease. Recently, the QRESEARCH risk estimator version 3 (QRISK3) calculator has been launched for CV risk assessment in the general population. QRISK3 now includes the presence of SLE as one of its variables for calculating CV risk. Our objective was to compare the predictive capacity between QRISK3 and the Systematic Coronary Risk Evaluation (SCORE) for the presence of subclinical carotid atherosclerosis in patients with SLE. Methods Two hundred and ninety-six patients with SLE were recruited. The presence of subclinical atherosclerosis was evaluated by carotid ultrasound to identify carotid plaque and the thickness of the carotid intima–media (cIMT). QRISK3 and SCORE were calculated. The relationship of QRISK3 and SCORE with each other and with the presence of subclinical carotid atherosclerosis (both carotid plaque and cIMT) was studied. Results There was no correlation between SCORE and QRISK3 in patients with SLE (Spearman’s rho = −0.008, P = 0.90). Although QRISK3 showed a statistically significant correlation with cIMT (Spearman’s rho = 0.420, P = 0.000), this relationship was not found between SCORE and cIMT (Spearman’s rho = −0.005, P = 0.93). The discrimination capacity of QRISK3 for the presence of carotid plaque was statistically significant and superior to that of SCORE (AUC 0.765 [95% CI: 0.711, 0.820] vs 0.561 [95% CI: 0.494, 0.629], P = 0.000). Conclusion QRISK3 discrimination for subclinical atherosclerosis is higher than that of SCORE. QRISK3, and not SCORE, should be used for the calculation of CV risk in patients with SLE.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>34240117</pmid><doi>10.1093/rheumatology/keab531</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0197-5267</orcidid></addata></record>
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subjects Atherosclerosis - etiology
Cardiovascular Diseases - epidemiology
Carotid Artery Diseases - complications
Carotid Artery Diseases - etiology
Carotid Intima-Media Thickness
Humans
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - epidemiology
Plaque, Atherosclerotic - complications
Plaque, Atherosclerotic - etiology
Risk Factors
title QRISK3 relation to carotid plaque is higer than that of score in patients with systemic lupus erythematosus
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