Analytical Sensitivity and Specificity of Four Point of Care Rapid Antigen Diagnostic Tests for SARS-CoV-2 Using Real-Time Quantitative PCR, Quantitative Droplet Digital PCR, and a Mass Spectrometric Antigen Assay as Comparator Methods

Abstract Background We evaluated the analytical sensitivity and specificity of 4 rapid antigen diagnostic tests (Ag RDTs) for severe acute respiratory syndrome coronavirus 2, using reverse transcription quantitative PCR (RT-qPCR) as the reference method and further characterizing samples using dropl...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2021-11, Vol.67 (11), p.1545-1553
Hauptverfasser:	Karon, Brad S, Donato, Leslie J, Bridgeman, Amber R, Blommel, Joseph H, Kipp, Benjamin, Maus, Anthony, Renuse, Santosh, Kemp, Jennifer, Madugundu, Anil K, Vanderboom, Patrick M, Chavan, Sandip, Dasari, Surendra, Singh, Ravinder J, Grebe, Stefan K, Pandey, Akhilesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Comparative analysis Coronaviruses Diagnostic systems Diagnostic tests Droplets Evaluation Fluorescence Immunoassay Mass spectrometry Mathematical analysis Medical diagnosis Medical tests Methods Polymerase chain reaction Reverse transcription Sensitivity analysis Severe acute respiratory syndrome coronavirus 2 Spectrometry Viral diseases
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