Fracture behavior of human cortical bone: Role of advanced glycation end-products and microstructural features

Diabetes is associated with increased fracture risk in human bone, especially in the elderly population. In the present study, we investigate how simulated advanced glycation end-products (AGEs) and materials heterogeneity affect crack growth trajectory in human cortical bone. We used a phase field...

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Veröffentlicht in:	Journal of biomechanics 2021-08, Vol.125, p.110600-110600, Article 110600
Hauptverfasser:	Maghami, Ebrahim, Josephson, Timothy O., Moore, Jason P., Rezaee, Taraneh, Freeman, Theresa A., Karim, Lamya, Najafi, Ahmad R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycation end-products Advanced glycosylation end products Age Biomedical materials Bones Cement Cortical bone Cortical bone microstructure Crack propagation Critical energy release rate Diabetes Diabetes mellitus Energy release rate Fractures Fragility Glycosylation Heterogeneity Investigations Mechanical properties Microstructure Osteons Phase-field modeling Population studies Two dimensional models
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