Boosting stem cell immunity to viruses

A newly discovered isoform of Dicer protects stem cells by enhancing antiviral RNA interference Mammalian stem cells exhibit deficiencies in innate immunity regulated by interferons (IFNs), so they rely on constitutive expression of some IFN-stimulated genes (ISGs) ( 1 ) and Argonaute 2 (AGO2)–depen...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-07, Vol.373 (6551), p.160-161
Hauptverfasser:	Shahrudin, Shabihah, Ding, Shou-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Argonaute 2 protein Coronaviruses Disease resistance Double-stranded RNA Embryo cells Gene expression Immunity Immunization, Secondary Innate immunity Interferon Intermediates Mammals Replicative intermediates Ribonucleic acid RNA RNA viruses RNA-induced silencing complex RNA-mediated interference Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 siRNA Stem cell transplantation Stem Cells Vector-borne diseases Viral diseases Viruses
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