Addition of Allenylzinc Reagents, Prepared in Situ from Nonracemic Propargylic Mesylates, to Aldehydes. A New Synthesis of Highly Enantioenriched Homopropargylic Alcohols

Enantioenriched propargylic mesylates are converted to chiral allenylzinc reagents via transient allenylpalladium species by treatment with a Pd(0)-phosphine catalyst in the presence of excess Et2Zn. These zinc reagents undergo SE2‘ additions to various aldehydes to yield mainly the anti homoproparg...

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Veröffentlicht in:	Journal of organic chemistry 1999-07, Vol.64 (14), p.5201-5204
Hauptverfasser:	Marshall, James A, Adams, Nicholas D
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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